(S)-N-(2-bromophenyl)-N-[(2-cyanomethyl)-2-cyclohexenyl]-4-methylbenzenesulfonamide

Base Information

Chemical Name:(S)-N-(2-bromophenyl)-N-[(2-cyanomethyl)-2-cyclohexenyl]-4-methylbenzenesulfonamide
CAS No.:350677-98-4
Molecular Formula:C₂₁H₂₁BrN₂O₂S
Molecular Weight:445.38
Hs Code.:

Synonyms:(S)-N-(2-bromophenyl)-N-[(2-cyanomethyl)-2-cyclohexenyl]-4-methylbenzenesulfonamide

Suppliers and Price of (S)-N-(2-bromophenyl)-N-[(2-cyanomethyl)-2-cyclohexenyl]-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-(2-bromophenyl)-N-[(2-cyanomethyl)-2-cyclohexenyl]-4-methylbenzenesulfonamide

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Technology Process of (S)-N-(2-bromophenyl)-N-[(2-cyanomethyl)-2-cyclohexenyl]-4-methylbenzenesulfonamide

There total 10 articles about (S)-N-(2-bromophenyl)-N-[(2-cyanomethyl)-2-cyclohexenyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 143-33-9,25596-52-5
sodium cyanide

: 350678-16-9
(S)-N-[(2-bromomethyl)-2-cyclohexenyl]-N-(2-bromophenyl)-4-methylbenzenesulfonamide

: 350677-98-4
(S)-N-(2-bromophenyl)-N-[(2-cyanomethyl)-2-cyclohexenyl]-4-methylbenzenesulfonamide

Guidance literature:: In dimethyl sulfoxide; at 20 ℃; for 1h;
DOI:10.1021/ol0159571 DOI:10.1021/ja029382u

Reference yield:

: 1024-38-0
N-(2-bromophenyl)-4-methylbenzenesulfonamide

: 350677-98-4
(S)-N-(2-bromophenyl)-N-[(2-cyanomethyl)-2-cyclohexenyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: Pd₂dba3*CHCl₃; (S)-BINAPO / dimethylformamide / 21 h / 0 °C

2: 100 percent / aq. HCl / tetrahydrofuran / 1 h / 20 °C

3: 90 percent / PBr₃ / tetrahydrofuran / 1.5 h / 0 - 20 °C

4: 95 percent / dimethylsulfoxide / 1 h / 20 °C

With hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; phosphorus tribromide; (S)-1,1'-binaphthalene-2,2'-diylbis(diphenylphosphine oxide); In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja029382u

Reference yield:

: 238434-65-6
2-(hydroxymethyl)cyclohex-2-en-1-ol

: 350677-98-4
(S)-N-(2-bromophenyl)-N-[(2-cyanomethyl)-2-cyclohexenyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / imidazole / dimethylformamide / 1.5 h / 0 °C

2: 96 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

3: Pd₂dba3*CHCl₃; (S)-BINAPO / dimethylformamide / 21 h / 0 °C

4: 100 percent / aq. HCl / tetrahydrofuran / 1 h / 20 °C

5: 90 percent / PBr₃ / tetrahydrofuran / 1.5 h / 0 - 20 °C

6: 95 percent / dimethylsulfoxide / 1 h / 20 °C

With pyridine; 1H-imidazole; hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; phosphorus tribromide; (S)-1,1'-binaphthalene-2,2'-diylbis(diphenylphosphine oxide); In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja029382u