N-(2-bromophenyl)-4-methylbenzene-1-sulfonamide

Base Information

• Chemical Name: N-(2-bromophenyl)-4-methylbenzene-1-sulfonamide
• CAS No.: 1024-38-0
• Molecular Formula: C13H12BrNO2S
• Molecular Weight: 326.214
• DSSTox Substance ID: DTXSID20355180
• Nikkaji Number: J1.414.994E
• Wikidata: Q82133895
• Mol file: 1024-38-0.mol

Synonyms:1024-38-0;N-(2-bromophenyl)-4-methylbenzene-1-sulfonamide;N-(2-bromophenyl)-4-methylbenzenesulfonamide;Benzenesulfonamide, N-(2-bromophenyl)-4-methyl-;2-bromo-N-tosylaniline;CBDivE_014066;SCHEMBL9903086;DTXSID20355180;BAA02438;STL123034;AKOS000177527;CS-0260956;EN300-76384;Z45619906;N-(2-BROMO-PHENYL)-4-METHYL-BENZENESULFONAMIDE

Chemical Property of N-(2-bromophenyl)-4-methylbenzene-1-sulfonamide

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 324.97721
• Heavy Atom Count: 18
• Complexity: 358

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2Br

Technology Process of N-(2-bromophenyl)-4-methylbenzene-1-sulfonamide

There total 2 articles about N-(2-bromophenyl)-4-methylbenzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

p-toluenesulfonyl chloride (98-59-9) + 2-bromoaniline (615-36-1) → N-(2-bromophenyl)-4-methylbenzenesulfonamide (1024-38-0)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/chem.201301800

Reference yield: 53.0%

chloroamine-T (127-65-1) + (2-bromophenyl)boronic acid (244205-40-1) → N-(2-bromophenyl)-4-methylbenzenesulfonamide (1024-38-0)

Guidance literature:

With ethanol; potassium tert-butylate; copper diacetate; at 20 ℃; for 12h;

DOI:10.1055/s-0036-1590978

Reference yield: 100.0%

N-(2-bromophenyl)-4-methylbenzenesulfonamide (1024-38-0) + 1-((tert-butyldimethylsilyl)oxy)-1-phenyl-4-(trimethylsilyl)but-3-yn-2-ol → N-(2-bromophenyl)-N-(1-((tert-butyldimethylsilyl)oxy)-1-phenyl-4-(trimethylsilyl)but-3-yn-2-yl)-4-methylbenzenesulfonamide

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/acs.orglett.8b03732

upstream raw materials:

p-toluenesulfonyl chloride

2-bromoaniline

chloroamine-T

(2-bromophenyl)boronic acid

Downstream raw materials:

N-p-toluenesulfonyl-2-vinylaniline

N-(3-Benzyloxy-2-oxo-propyl)-N-(2-bromo-phenyl)-4-methyl-benzenesulfonamide

2-Brom-N-<4-nitro-benzyl>-N-p-toluolsulfonyl-anilin

N-(2-bromophenyl)-N-methyl-p-toluenesulfonamide