4-bromo-1-(2,2-difluoropropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

Base Information

Chemical Name:4-bromo-1-(2,2-difluoropropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole
CAS No.:1221503-33-8
Molecular Formula:C₁₃H₁₂BrF₃N₂
Molecular Weight:333.151
Hs Code.:

Synonyms:4-bromo-1-(2,2-difluoropropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

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Chemical Property of 4-bromo-1-(2,2-difluoropropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

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Technology Process of 4-bromo-1-(2,2-difluoropropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

There total 5 articles about 4-bromo-1-(2,2-difluoropropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1221503-32-7
1-[4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]propan-2-one

: 1221503-33-8
4-bromo-1-(2,2-difluoropropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 20 ℃;

Reference yield:

: 29681-98-9
p-fluorobenzoylacetone

: 1221503-33-8
4-bromo-1-(2,2-difluoropropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; trifluoroacetic acid / isopropyl alcohol / 7 h / 80 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.25 h / 0 °C

3.1: water; sodium hydroxide / methanol / 3 h / 20 °C

3.3: 12 h / 20 °C

4.1: tetrahydrofuran / 0 - 20 °C

5.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

With N-Bromosuccinimide; diethylamino-sulfur trifluoride; water; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1221503-30-5
ethyl [4-bromo-5-(4-fluorophenyl)-3-methyl-1H-pyrazol-1-yl]acetate

: 1221503-33-8
4-bromo-1-(2,2-difluoropropyl)-5-(4-fluorophenyl)-3-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / methanol / 3 h / 20 °C

1.3: 12 h / 20 °C

2.1: tetrahydrofuran / 0 - 20 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

With diethylamino-sulfur trifluoride; water; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;