2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide

Base Information

Chemical Name:2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide
CAS No.:1228024-61-0
Molecular Formula:C₂₈H₄₁FN₂O
Molecular Weight:440.645
Hs Code.:

Synonyms:2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide

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Chemical Property of 2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide

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Technology Process of 2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide

There total 6 articles about 2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228024-50-7
2,2-dicyclohexyl-N-[(3aS,4S,6aR)-octahydrocyclopenta[c]pyrrol-4-yl]acetamide

: 456-48-4
3-Fluorobenzaldehyde

: 1228024-61-0
2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide

Guidance literature:: With acetic acid; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.04.057

Reference yield:

: 1384106-78-8
(R,E)-N-((3aS,6aR)-2-benzylhexahydrocyclopenta[c]pyrrol-4(5H)-ylidene)-2-methylpropane-2-sulfinamide

: 1228024-61-0
2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / methanol / 16 h / -78 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: hydrogenchloride; water / methanol / 0.5 h / 20 °C / Inert atmosphere

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 h / 20 °C / Inert atmosphere

4.1: 20 % Pd(OH)2/C; hydrogen / methanol / 16 h / 20 °C / 1551.49 Torr

5.1: acetic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; 20 % Pd(OH)2/C; water; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2012.04.057

Reference yield:

: 1384106-80-2
(R)-N-((3aS,4S,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl)-2-methylpropane-2-sulfinamide

: 1228024-61-0
2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; water / methanol / 0.5 h / 20 °C / Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 h / 20 °C / Inert atmosphere

3: 20 % Pd(OH)2/C; hydrogen / methanol / 16 h / 20 °C / 1551.49 Torr

4: acetic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; 20 % Pd(OH)2/C; water; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2012.04.057