(S)-2-tert-butoxy-2-(1-(4,4-dimethylcyclohex-1-enyl)-3-methylnaphthalen-2-yl)acetic acid

Base Information

Chemical Name:(S)-2-tert-butoxy-2-(1-(4,4-dimethylcyclohex-1-enyl)-3-methylnaphthalen-2-yl)acetic acid
CAS No.:1354489-42-1
Molecular Formula:C₂₅H₃₂O₃
Molecular Weight:380.527
Hs Code.:

Synonyms:(S)-2-tert-butoxy-2-(1-(4,4-dimethylcyclohex-1-enyl)-3-methylnaphthalen-2-yl)acetic acid

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Chemical Property of (S)-2-tert-butoxy-2-(1-(4,4-dimethylcyclohex-1-enyl)-3-methylnaphthalen-2-yl)acetic acid

Chemical Property:

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Technology Process of (S)-2-tert-butoxy-2-(1-(4,4-dimethylcyclohex-1-enyl)-3-methylnaphthalen-2-yl)acetic acid

There total 11 articles about (S)-2-tert-butoxy-2-(1-(4,4-dimethylcyclohex-1-enyl)-3-methylnaphthalen-2-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354491-07-8
(S)-ethyl 2-tert-butoxy-2-(1-(4,4-dimethylcyclohex-1-enyl)-3-methylnaphthalen-2-yl)acetate

: 1354489-42-1
(S)-2-tert-butoxy-2-(1-(4,4-dimethylcyclohex-1-enyl)-3-methylnaphthalen-2-yl)acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; ethanol; at 35 ℃;

Reference yield:

: 17324-04-8
3-methyl-naphthalen-2-ol

: 1354489-42-1
(S)-2-tert-butoxy-2-(1-(4,4-dimethylcyclohex-1-enyl)-3-methylnaphthalen-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-chloro-succinimide / zirconium(IV) chloride / dichloromethane / 5.08 h / -78 - 20 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 3 h / -78 °C

3.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / 28 h / 50 - 80 °C / Inert atmosphere

4.1: (DHQ)₂PHAL / water; tert-butyl alcohol / 8 h / 0 °C

5.1: pyridine / dichloromethane / 19 h / 20 °C

6.1: perchloric acid / 1.5 h / 20 °C

6.2: 1 h

7.1: sodium hydroxide; methanol / tetrahydrofuran / 20 °C

8.1: chromium(VI) oxide; periodic acid / acetonitrile; water / 2 h / 0 °C

9.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

10.1: potassium dihydrogenphosphate / (2-dicyclohexyl-phosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) chloride methyl-t-butyl ether adduct / tetrahydrofuran / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

11.1: water; lithium hydroxide / ethanol; tetrahydrofuran / 35 °C

With pyridine; 2,6-dimethylpyridine; chromium(VI) oxide; methanol; potassium dihydrogenphosphate; N-chloro-succinimide; perchloric acid; (DHQ)₂PHAL; water; caesium carbonate; periodic acid; lithium chloride; sodium hydroxide; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; (2-dicyclohexyl-phosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) chloride methyl-t-butyl ether adduct; zirconium(IV) chloride; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1322036-27-0
1-chloro-3-methyl-naphthalen-2-ol

: 1354489-42-1
(S)-2-tert-butoxy-2-(1-(4,4-dimethylcyclohex-1-enyl)-3-methylnaphthalen-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 3 h / -78 °C

2.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / 28 h / 50 - 80 °C / Inert atmosphere

3.1: (DHQ)₂PHAL / water; tert-butyl alcohol / 8 h / 0 °C

4.1: pyridine / dichloromethane / 19 h / 20 °C

5.1: perchloric acid / 1.5 h / 20 °C

5.2: 1 h

6.1: sodium hydroxide; methanol / tetrahydrofuran / 20 °C

7.1: chromium(VI) oxide; periodic acid / acetonitrile; water / 2 h / 0 °C

8.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

9.1: potassium dihydrogenphosphate / (2-dicyclohexyl-phosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) chloride methyl-t-butyl ether adduct / tetrahydrofuran / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

10.1: water; lithium hydroxide / ethanol; tetrahydrofuran / 35 °C

With pyridine; 2,6-dimethylpyridine; chromium(VI) oxide; methanol; potassium dihydrogenphosphate; perchloric acid; (DHQ)₂PHAL; water; caesium carbonate; periodic acid; lithium chloride; sodium hydroxide; lithium hydroxide; bis-triphenylphosphine-palladium(II) chloride; (2-dicyclohexyl-phosphino-2',6'-dimethoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) chloride methyl-t-butyl ether adduct; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;