2-{(1S,2S)-2-[1-(Imidazole-1-carbothioyloxy)-6-methoxycarbonyl-hexyl]-3-oxo-cyclopentyl}-2-methyl-malonic acid dibenzyl ester

Base Information

Chemical Name:2-{(1S,2S)-2-[1-(Imidazole-1-carbothioyloxy)-6-methoxycarbonyl-hexyl]-3-oxo-cyclopentyl}-2-methyl-malonic acid dibenzyl ester
CAS No.:207991-54-6
Molecular Formula:C₃₅H₄₀N₂O₈S
Molecular Weight:648.777
Hs Code.:

Synonyms:2-{(1S,2S)-2-[1-(Imidazole-1-carbothioyloxy)-6-methoxycarbonyl-hexyl]-3-oxo-cyclopentyl}-2-methyl-malonic acid dibenzyl ester

Suppliers and Price of 2-{(1S,2S)-2-[1-(Imidazole-1-carbothioyloxy)-6-methoxycarbonyl-hexyl]-3-oxo-cyclopentyl}-2-methyl-malonic acid dibenzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{(1S,2S)-2-[1-(Imidazole-1-carbothioyloxy)-6-methoxycarbonyl-hexyl]-3-oxo-cyclopentyl}-2-methyl-malonic acid dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-{(1S,2S)-2-[1-(Imidazole-1-carbothioyloxy)-6-methoxycarbonyl-hexyl]-3-oxo-cyclopentyl}-2-methyl-malonic acid dibenzyl ester

There total 1 articles about 2-{(1S,2S)-2-[1-(Imidazole-1-carbothioyloxy)-6-methoxycarbonyl-hexyl]-3-oxo-cyclopentyl}-2-methyl-malonic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 2-[(1S,2S)-2-(1-Hydroxy-6-methoxycarbonyl-hexyl)-3-oxo-cyclopentyl]-2-methyl-malonic acid dibenzyl ester

: 207991-54-6
2-{(1S,2S)-2-[1-(Imidazole-1-carbothioyloxy)-6-methoxycarbonyl-hexyl]-3-oxo-cyclopentyl}-2-methyl-malonic acid dibenzyl ester

Guidance literature:: With dmap; In acetonitrile;
DOI:10.1021/jo9723319

Reference yield: 46.0%

: 207991-54-6
2-{(1S,2S)-2-[1-(Imidazole-1-carbothioyloxy)-6-methoxycarbonyl-hexyl]-3-oxo-cyclopentyl}-2-methyl-malonic acid dibenzyl ester

: 207991-40-0
2-[(1S,2R)-2-(6-Methoxycarbonyl-hexyl)-3-oxo-cyclopentyl]-2-methyl-malonic acid dibenzyl ester

Guidance literature:: With di-tert-butyl peroxide; tri-n-butyl-tin hydride; at 50 ℃;
DOI:10.1021/jo9723319

Reference yield:

: 207991-54-6
2-{(1S,2S)-2-[1-(Imidazole-1-carbothioyloxy)-6-methoxycarbonyl-hexyl]-3-oxo-cyclopentyl}-2-methyl-malonic acid dibenzyl ester

: 207991-41-1
2-[(1S,2R,3S)-3-Hydroxy-2-(6-methoxycarbonyl-hexyl)-cyclopentyl]-2-methyl-malonic acid dibenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 46 percent / Bu₃SnH, (t-BuO)2 / 50 °C

2: 88 percent / L-Selectride / CH₂Cl₂; tetrahydrofuran / 1 h / -78 °C

With di-tert-butyl peroxide; tri-n-butyl-tin hydride; L-Selectride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9723319