N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-histidine benzyl ester

Base Information

• Chemical Name: N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-histidine benzyl ester
• CAS No.: 1185198-35-9
• Molecular Formula: C₂₈H₃₁ClN₈O₄
• Molecular Weight: 579.058

Synonyms:N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-histidine benzyl ester

Chemical Property of N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-histidine benzyl ester

Chemical Property:

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Technology Process of N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-histidine benzyl ester

There total 2 articles about N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-histidine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine (1185198-27-9) + L-histidine benzyl ester p-toluenesulfonate (906324-05-8) → N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-histidine benzyl ester (1185198-35-9)

Guidance literature:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

L-histidine benzyl ester p-toluenesulfonate; With 4-methyl-morpholine; In tetrahydrofuran; at 20 ℃; for 0.333333h; pH=9;

In tetrahydrofuran; at 0 - 20 ℃; for 50h;

DOI:10.1016/j.bmc.2009.07.035

Reference yield:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine (1185198-27-9) + L-histidine benzyl ester (46921-20-4) → N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-histidine benzyl ester (1185198-35-9)

Guidance literature:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

L-histidine benzyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 50h;

DOI:10.1016/j.bmcl.2009.05.077

Reference yield: 93.0%

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-histidine benzyl ester (1185198-35-9) → N-(2-chloro-9H-purin-6-yl)-N-cyclopropylglycyl-L-histidine benzyl ester (1185198-55-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃;

DOI:10.1016/j.bmc.2009.07.035

upstream raw materials:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine

L-histidine benzyl ester

L-histidine benzyl ester p-toluenesulfonate

Downstream raw materials:

N-(2-chloro-9H-purin-6-yl)-N-cyclopropylglycyl-L-histidine benzyl ester

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