Technology Process of C10H13BrO4
There total 1 articles about C10H13BrO4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide;
In
acetonitrile;
for 3h;
regioselective reaction;
Inert atmosphere;
DOI:10.1016/j.tetlet.2011.05.091
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere; Reflux
2.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 1.17 h / -78 - 20 °C / Inert atmosphere
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
3.2: 2 h / Inert atmosphere
4.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Inert atmosphere; Reflux
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.83 h / 0 °C / Inert atmosphere
6.1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere; Reflux
7.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 0 - 20 °C / Inert atmosphere
7.2: 1 h / Inert atmosphere; Reflux
With
sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; dimethyl sulfoxide; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
2.1: Swern oxidation / 3.1: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.tetlet.2011.05.091
