N-[4-(1-Hydroxy-4-methyl-5-pyridin-3-yl-1H-imidazol-2-yl)-2-nitro-phenyl]-acetamide

Base Information

• Chemical Name: N-[4-(1-Hydroxy-4-methyl-5-pyridin-3-yl-1H-imidazol-2-yl)-2-nitro-phenyl]-acetamide
• CAS No.: 126436-35-9
• Molecular Formula: C₁₇H₁₅N₅O₄
• Molecular Weight: 353.337

Synonyms:N-[4-(1-Hydroxy-4-methyl-5-pyridin-3-yl-1H-imidazol-2-yl)-2-nitro-phenyl]-acetamide

Chemical Property of N-[4-(1-Hydroxy-4-methyl-5-pyridin-3-yl-1H-imidazol-2-yl)-2-nitro-phenyl]-acetamide

Chemical Property:

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Technology Process of N-[4-(1-Hydroxy-4-methyl-5-pyridin-3-yl-1H-imidazol-2-yl)-2-nitro-phenyl]-acetamide

There total 2 articles about N-[4-(1-Hydroxy-4-methyl-5-pyridin-3-yl-1H-imidazol-2-yl)-2-nitro-phenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-hydroxyimino-1-(3-pyridyl)-2-propanone (65882-96-4) + 4-acetamido-3-nitrobenzaldehyde (51818-98-5) → N-[4-(1-Hydroxy-4-methyl-5-pyridin-3-yl-1H-imidazol-2-yl)-2-nitro-phenyl]-acetamide (126436-35-9)

Guidance literature:

With ammonium acetate; In acetic acid; at 100 ℃; for 0.25h;

DOI:10.1248/cpb.42.560

Reference yield:

para-acetamidobenzaldehyde (122-85-0) → N-[4-(1-Hydroxy-4-methyl-5-pyridin-3-yl-1H-imidazol-2-yl)-2-nitro-phenyl]-acetamide (126436-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 50.2 percent / HNO₃ fuming / 0.67 h / -40 - -20 °C

2: ammonium acetate / acetic acid / 0.25 h / 100 °C

With ammonium acetate; nitric acid; In acetic acid;

DOI:10.1248/cpb.42.560

Reference yield: 55.2%

N-[4-(1-Hydroxy-4-methyl-5-pyridin-3-yl-1H-imidazol-2-yl)-2-nitro-phenyl]-acetamide (126436-35-9) → N-[4-(5-Methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-2-nitro-phenyl]-acetamide (126436-45-1)

Guidance literature:

With triethyl phosphite; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1248/cpb.42.560

upstream raw materials:

1-hydroxyimino-1-(3-pyridyl)-2-propanone

4-acetamido-3-nitrobenzaldehyde

para-acetamidobenzaldehyde

Downstream raw materials:

N-[4-(5-Methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-2-nitro-phenyl]-acetamide

N-[2-Amino-4-(5-methyl-4-pyridin-3-yl-1H-imidazol-2-yl)-phenyl]-acetamide

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