51818-98-5

Usage

InChI:InChI=1/C9H8N2O4/c1-6(13)10-8-3-2-7(5-12)4-9(8)11(14)15/h2-5H,1H3,(H,10,13)

Upstream product

• 64818-14-0 1-acetylamino-4-diacetoxymethyl-2-nitro-benzene 
• 122-85-0 para-acetamidobenzaldehyde 
• 73166-06-0 4-(hydroxymethyl)-2-nitroacetanilide 
• 1539-06-6 3-nitro-4-acetamidobenzoic acid 
• 7647-01-0 hydrogenchloride 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 7664-93-9 sulfuric acid 

Downstream Products

• 106873-46-5 4-Acetamido-3-nitrocinnamic acid 
• 24364-02-1 4-amino-3-nitro-cinnamic acid 
• 85574-08-9 N-[4-(Di-piperidin-1-yl-methyl)-2-nitro-phenyl]-acetamide 
• 128618-50-8 N-{4-[(E)-2-(3,7-Dimethyl-imidazo[1,2-a]pyridin-2-yl)-vinyl]-2-nitro-phenyl}-acetamide 
• 106873-42-1 α-Phenyl-(3-nitro-4-amino)cinnamonitril 
• 100804-39-5 (E)-3-(4-Amino-3-nitro-phenyl)-1-phenyl-propenone 
• 100804-37-3 (E)-4-(4-Amino-3-nitro-phenyl)-but-3-en-2-one 
• 78807-37-1 N-[4-(5-Methoxy-1H-benzoimidazol-2-yl)-2-nitro-phenyl]-acetamide 
• 742676-79-5 N-[4-(5-Carbamimidoyl-1H-benzoimidazol-2-yl)-2-nitro-phenyl]-acetamide 
• 3011-34-5 4-hydroxy-3-nitrobenzaldehyde 
• 51818-99-6 4-amino-3-nitro-benzaldehyde 
• 713511-80-9 (E)-3-(4-Acetylamino-3-nitro-phenyl)-2-methyl-acrylic acid ethyl ester 
• 604815-08-9 C₂₁H₂₂N₄O₃ 
• 78807-35-9 N-[4-(1H-Benzoimidazol-2-yl)-2-nitro-phenyl]-acetamide 

Relevant academic research and scientific papers

Agile Detection of Chemical Warfare Agents by Machine Vision: a Supramolecular Approach

The supramolecular detection by image analysis of a simulant chemical warfare agent on a solid device containing a selective molecular sensor based on a BODIPY scaffold is reported. The recognition properties were investigated in solution, demonstrating h

Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors

Abstract Protein-protein interactions are critical for regulating the activity of translation initiation factors and multitude of other cellular process, and form the largest block of untapped albeit most challenging targets for drug development. 4EGI-1, (E/Z)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl) hydrazono)-3-(2-nitrophenyl)propanoic acid, is a hit compound discovered in a screening campaign of small molecule libraries as an inhibitor of translation initiation factors eIF4E and eIF4G protein-protein interaction; it inhibits translation initiation in vitro and in vivo. A series of 4EGI-1-derived thiazol-2-yl hydrazones have been designed and synthesized in order to delineate the structural latitude and improve its binding affinity to eIF4E, and increase its potency in inhibiting the eIF4E/eIF4G interaction. Probing a wide range of substituents on both phenyl rings comprising the 3-phenylpropionic acid and 4-phenylthiazolidine moieties in the context of both E- and Z-isomers of 4EGI-1 led to analogs with enhanced binding affinity and translation initiation inhibitory activities.

Design of a highly sensitive fluorescent probe for interfacial electron transfer on a TiO2 surface

Single-molecule fluorescent probe: The formation of the highly fluorescent 4-NHOH form of a 3,4-dinitrophenyl-substituted boron dipyrromethane dye can be used to study interfacial electron transfer on individual TiO2 particles (see picture; B yellow, C gray, F green, H white, O red). Kinetic and image analyses of the resulting fluorescence bursts reveal temporal dynamics of molecular interactions and reactive-site distributions.

New benzimidazoles as thrombopoietin receptor agonists

A novel benzimidazole series of small-molecule thrombopoietin receptor agonists has been discovered. Herein, we discuss the preliminary exploration of structure-activity relationships within this chemotype.

FLUORESCENT PROBES

A compound represented by the formula (I) wherein R1 and R2 represent amino groups that substitute at adjacent positions on the benzene ring, wherein one of the amino groups may have one alkyl group; R3 and R4 r

Colorimetric detection of chemical warfare simulants

Two simple chromogenic indicators (4) and (5), containing different supernucleophilic moieties, have been synthesized. Upon phosphorylation with two chemical warfare agent (CWA) simulants, a hypsochromic shift of approximately 50 nm is observed in an NaOH

HETEROCYCLIC KINASE INHIBITORS

Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Highly Sensitive Fluorescence Probes for Nitric Oxide Based on Boron Dipyrromethene Chromophore - Rational Design of Potentially Useful Bioimaging Fluorescence Probe

Boron dipyrromethene (BODIPY) is known to have a high quantum yield (φ) of fluorescence in aqueous solution but has not been utilized much for biological applications, compared to fluorescein. We developed 8-(3,4-diaminophenyl)-2,6-bis(2-carboxyethyl)-4,4

Studies on anti-platelet agents. II. Synthesis and platelet-inhibitory activity of 5-methyl-4-(3-pyridyl)-2-(substituted benzimidazol-5- yl)imidazoles

A series of 5-methyl-4-(3-pyridyl)-2-(substituted benzimidazol-5- yl)imidazole derivatives was synthesized and tested for anti-platelet and vasodilatory activities. Some compounds were found to have potent activities and low acute toxicity. In particular,