(S)-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-phenyl-acetic acid cyclopentyl ester

Base Information

Chemical Name:(S)-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-phenyl-acetic acid cyclopentyl ester
CAS No.:914645-11-7
Molecular Formula:C₂₆H₄₀N₂O₄
Molecular Weight:444.615
Hs Code.:

Synonyms:(S)-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-phenyl-acetic acid cyclopentyl ester

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Chemical Property of (S)-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-phenyl-acetic acid cyclopentyl ester

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Technology Process of (S)-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-phenyl-acetic acid cyclopentyl ester

There total 5 articles about (S)-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-phenyl-acetic acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 916210-80-5
trans-4-(N-tert-butoxycarbonylaminomethyl)cyclohexane carboxaldehyde

: 205180-16-1
cyclopentyl (2S)-amino(phenyl)acetate

: 914645-11-7
(S)-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-phenyl-acetic acid cyclopentyl ester

Guidance literature:: trans-4-(N-tert-butoxycarbonylaminomethyl)cyclohexane carboxaldehyde; cyclopentyl (2S)-amino(phenyl)acetate; In 1,1-dichloroethane; at 20 ℃; for 0.416667h;

With sodium tris(acetoxy)borohydride; acetic acid; In 1,1-dichloroethane; at 20 ℃; for 1.5h;

Reference yield:

: 162046-58-4
4-(N-tert-butyloxycarbonylaminomethyl)-cyclohexane-1-carboxylic acid

: 914645-11-7
(S)-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-phenyl-acetic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran; 1,4-dioxane / 0 - 20 °C

2.1: Dess-Martin periodane / dichloromethane / 3 h / -78 - 20 °C

3.1: 1,1-dichloroethane / 0.42 h / 20 °C

3.2: 1.5 h / 20 °C

With lithium aluminium tetrahydride; Dess-Martin periodane; In tetrahydrofuran; 1,4-dioxane; 1,1-dichloroethane; dichloromethane;

Reference yield:

: tranexamic acid

: 914645-11-7
(S)-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexylmethyl]-amino}-phenyl-acetic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 5 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran; 1,4-dioxane / 0 - 20 °C

3.1: Dess-Martin periodane / dichloromethane / 3 h / -78 - 20 °C

4.1: 1,1-dichloroethane / 0.42 h / 20 °C

4.2: 1.5 h / 20 °C

With sodium hydroxide; lithium aluminium tetrahydride; Dess-Martin periodane; In tetrahydrofuran; 1,4-dioxane; 1,1-dichloroethane; dichloromethane; water;