3β,17α-dihydroxy-16β-(dimethylphenylsilyl)-17β-methyl-D-homoandrost-5-en-17a-one

Base Information

Chemical Name:3β,17α-dihydroxy-16β-(dimethylphenylsilyl)-17β-methyl-D-homoandrost-5-en-17a-one
CAS No.:97350-94-2
Molecular Formula:C₂₉H₄₂O₃Si
Molecular Weight:466.736
Hs Code.:

Synonyms:3β,17α-dihydroxy-16β-(dimethylphenylsilyl)-17β-methyl-D-homoandrost-5-en-17a-one

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Chemical Property of 3β,17α-dihydroxy-16β-(dimethylphenylsilyl)-17β-methyl-D-homoandrost-5-en-17a-one

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Technology Process of 3β,17α-dihydroxy-16β-(dimethylphenylsilyl)-17β-methyl-D-homoandrost-5-en-17a-one

There total 6 articles about 3β,17α-dihydroxy-16β-(dimethylphenylsilyl)-17β-methyl-D-homoandrost-5-en-17a-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 97350-89-5
3β,17α-dihydroxy-16β-(dimethylphenylsilyl)pregn-5-en-20-one

: 97350-94-2
3β,17α-dihydroxy-16β-(dimethylphenylsilyl)-17β-methyl-D-homoandrost-5-en-17a-one

Guidance literature:: With boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1021/jo00219a031

Reference yield:

: 3839-31-4
dimethyl(phenyl)silyllithium

: 97350-94-2
3β,17α-dihydroxy-16β-(dimethylphenylsilyl)-17β-methyl-D-homoandrost-5-en-17a-one

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / tetrahydrofuran

2: 62 percent / tetrabutylammonium fluoride / tetrahydrofuran / Heating

3: BF₃*OEt₂ / tetrahydrofuran / 0.5 h / 0 °C

With boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/jo00219a031

Reference yield:

: 19454-86-5
20,20-ethanediyldioxy-16α,17-epoxy-pregn-5-en-3β-ol

: 97350-94-2
3β,17α-dihydroxy-16β-(dimethylphenylsilyl)-17β-methyl-D-homoandrost-5-en-17a-one

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide

2: 67 percent / tetrahydrofuran

3: 62 percent / tetrabutylammonium fluoride / tetrahydrofuran / Heating

4: BF₃*OEt₂ / tetrahydrofuran / 0.5 h / 0 °C

With 1H-imidazole; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo00219a031