3-(3-(tert-butyldimethylsilyloxy)propyl)-3-methylcyclohex-1-enyl trifluoromethanesulfonate

Base Information

Chemical Name:3-(3-(tert-butyldimethylsilyloxy)propyl)-3-methylcyclohex-1-enyl trifluoromethanesulfonate
CAS No.:1071178-89-6
Molecular Formula:C₁₇H₃₁F₃O₄SSi
Molecular Weight:416.577
Hs Code.:

Synonyms:3-(3-(tert-butyldimethylsilyloxy)propyl)-3-methylcyclohex-1-enyl trifluoromethanesulfonate

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Chemical Property of 3-(3-(tert-butyldimethylsilyloxy)propyl)-3-methylcyclohex-1-enyl trifluoromethanesulfonate

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Technology Process of 3-(3-(tert-butyldimethylsilyloxy)propyl)-3-methylcyclohex-1-enyl trifluoromethanesulfonate

There total 3 articles about 3-(3-(tert-butyldimethylsilyloxy)propyl)-3-methylcyclohex-1-enyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 75-16-1
methylmagnesium bromide

: 145100-51-2
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide

: 181312-41-4
3-(3-(tert-butyldimethylsilanyloxy)propyl)cyclohex-2-enone

: 1071178-89-6
3-(3-(tert-butyldimethylsilyloxy)propyl)-3-methylcyclohex-1-enyl trifluoromethanesulfonate

Guidance literature:: methylmagnesium bromide; With copper(l) iodide; In tetrahydrofuran; at -20 - 10 ℃; Inert atmosphere;

3-(3-(tert-butyldimethylsilanyloxy)propyl)cyclohex-2-enone; In tetrahydrofuran; at -20 - -10 ℃; Inert atmosphere;

N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulphonyl]methanesulphonamide; In tetrahydrofuran; at 20 ℃; for 19h; Inert atmosphere;
DOI:10.1002/chem.200800930

Reference yield:

: 61589-86-4
3-(3-hydroxy-propyl)cyclohex-2-en-1-one

: 1071178-89-6
3-(3-(tert-butyldimethylsilyloxy)propyl)-3-methylcyclohex-1-enyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

2.1: copper(l) iodide / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

2.2: 1 h / -20 °C / Inert atmosphere

2.3: -20 - 20 °C / Inert atmosphere

With 1H-imidazole; copper(l) iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c0ob01086c

Reference yield:

: 5323-87-5
3-Ethoxycyclohex-2-en-1-one

: 1071178-89-6
3-(3-(tert-butyldimethylsilyloxy)propyl)-3-methylcyclohex-1-enyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / -20 - 20 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

3.1: copper(l) iodide / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

3.2: 1 h / -20 °C / Inert atmosphere

3.3: -20 - 20 °C / Inert atmosphere

With 1H-imidazole; copper(l) iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c0ob01086c