ethyl 2-((4-methyl-N-(prop-2-ynyl)phenylsulfonamido)methyl)cycloprop-2-enecarboxylate

Base Information

• Chemical Name: ethyl 2-((4-methyl-N-(prop-2-ynyl)phenylsulfonamido)methyl)cycloprop-2-enecarboxylate
• CAS No.: 1250283-30-7
• Molecular Formula: C₁₇H₁₉NO₄S
• Molecular Weight: 333.408
• Mol file: 1250283-30-7.mol

Synonyms:ethyl 2-((4-methyl-N-(prop-2-ynyl)phenylsulfonamido)methyl)cycloprop-2-enecarboxylate

Chemical Property of ethyl 2-((4-methyl-N-(prop-2-ynyl)phenylsulfonamido)methyl)cycloprop-2-enecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of ethyl 2-((4-methyl-N-(prop-2-ynyl)phenylsulfonamido)methyl)cycloprop-2-enecarboxylate

There total 1 articles about ethyl 2-((4-methyl-N-(prop-2-ynyl)phenylsulfonamido)methyl)cycloprop-2-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

diazoacetic acid ethyl ester (623-73-4) + 4-methyl-N,N-diprop-2-ynylbenzenesulfonamide (18773-54-1) → ethyl 2-((4-methyl-N-(prop-2-ynyl)phenylsulfonamido)methyl)cycloprop-2-enecarboxylate (1250283-30-7)

Guidance literature:

With dirhodium tetraacetate; In dichloromethane; Reflux;

DOI:10.1021/ol101455c

Reference yield: 60.0%

ethyl 2-((4-methyl-N-(prop-2-ynyl)phenylsulfonamido)methyl)cycloprop-2-enecarboxylate (1250283-30-7) + allyltrimethoxysilane (2551-83-9) → ethyl 2-(1-tosyl-4-vinyl-2,5-dihydro-1H-pyrrol-3-yl)-5-(trimethoxysilyl)pent-3-enoate (1250283-65-8)

Guidance literature:

With Grubbs catalyst first generation; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol101455c

Reference yield:

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + ethyl 2-((4-methyl-N-(prop-2-ynyl)phenylsulfonamido)methyl)cycloprop-2-enecarboxylate (1250283-30-7) → (Z)-ethyl 4-phenyl-2-(1-tosyl-4-vinyl-2,5-dihydro-1H-pyrrol-3-yl)but-3-enoate (1250284-13-9) + (E)-ethyl 4-phenyl-2-(1-tosyl-4-vinyl-2,5-dihydro-1H-pyrrol-3-yl)but-3-enoate (1250284-09-3)

Guidance literature:

With Grubbs catalyst first generation; at 20 ℃; for 24h; optical yield given as %de; Inert atmosphere;

DOI:10.1021/ol101455c

upstream raw materials:

diazoacetic acid ethyl ester

4-methyl-N,N-diprop-2-ynylbenzenesulfonamide

Downstream raw materials:

(Z)-ethyl 4-phenyl-2-(1-tosyl-4-vinyl-2,5-dihydro-1H-pyrrol-3-yl)but-3-enoate

(E)-ethyl 4-phenyl-2-(1-tosyl-4-vinyl-2,5-dihydro-1H-pyrrol-3-yl)but-3-enoate

(Z)-ethyl 4-(4-methoxyphenyl)-2-(1-tosyl-4-vinyl-2,5-dihydro-1H-pyrrol-3-yl)but-3-enoate

(E)-ethyl 4-(4-methoxyphenyl)-2-(1-tosyl-4-vinyl-2,5-dihydro-1H-pyrrol-3-yl)but-3-enoate