2-benzyl-3-hydroxy-3-phenyl-6-azaindolinone

Base Information

• Chemical Name: 2-benzyl-3-hydroxy-3-phenyl-6-azaindolinone
• CAS No.: 104867-65-4
• Molecular Formula: C₂₀H₁₆N₂O₂
• Molecular Weight: 316.359
• Mol file: 104867-65-4.mol

Synonyms:2-benzyl-3-hydroxy-3-phenyl-6-azaindolinone

Chemical Property of 2-benzyl-3-hydroxy-3-phenyl-6-azaindolinone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-benzyl-3-hydroxy-3-phenyl-6-azaindolinone

There total 2 articles about 2-benzyl-3-hydroxy-3-phenyl-6-azaindolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

3-chloro-3-phenyl-6-azaphthalide hydrochloride (104867-63-2) + benzylamine (100-46-9) → 2-benzyl-3-hydroxy-3-phenyl-6-azaindolinone (104867-65-4)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 20 ℃; for 12h;

DOI:10.1007/BF00515426

Reference yield:

4-benzoylpyridine-3-carboxylic acid (74975-25-0) → 2-benzyl-3-hydroxy-3-phenyl-6-azaindolinone (104867-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / thionyl chloride / benzene / 4 h / Heating

2: 46 percent / triethylamine / dioxane / 12 h / 20 °C

With thionyl chloride; triethylamine; In 1,4-dioxane; benzene;

DOI:10.1007/BF00515426

upstream raw materials:

3-chloro-3-phenyl-6-azaphthalide hydrochloride

benzylamine

4-benzoylpyridine-3-carboxylic acid

Refernces