(3R,5RS,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3,7-dimethyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)-5-octanol

Base Information

Chemical Name:(3R,5RS,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3,7-dimethyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)-5-octanol
CAS No.:247256-58-2
Molecular Formula:C₃₇H₅₀F₃NO₄Si
Molecular Weight:657.889
Hs Code.:

Synonyms:(3R,5RS,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3,7-dimethyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)-5-octanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5RS,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3,7-dimethyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)-5-octanol

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Technology Process of (3R,5RS,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3,7-dimethyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)-5-octanol

There total 4 articles about (3R,5RS,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3,7-dimethyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)-5-octanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 5674-02-2
2-methylpropylmagnesium chloride

: 247256-57-1
(3R,1'S,2'S)-5-tert-Butyldiphenylsiloxy-3-methyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)-1-pentanal

: 247256-58-2
(3R,5RS,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3,7-dimethyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)-5-octanol

Guidance literature:: In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; for 4h;
DOI:10.1002/(SICI)1521-3765(19991001)5:10<2885::AID-CHEM2885>3.0.CO;2-8

Reference yield:

: 97250-25-4
tert-Butyldiphenylsilyl β-hydroxybutanone

: 247256-58-2
(3R,5RS,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3,7-dimethyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)-5-octanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / TfOH / CH₂Cl₂ / 5 h / -78 °C

2.1: O₃ / CH₂Cl₂; methanol / -78 °C

2.2: 95 percent / PPh₃ / 0.5 h / -78 °C

3.1: 96 percent / tetrahydrofuran; diethyl ether / 4 h / -78 - 20 °C

With trifluorormethanesulfonic acid; ozone; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1.1: Etherification / 2.1: Oxidation / 2.2: Reduction / 3.1: Grignard reaction;
DOI:10.1002/(SICI)1521-3765(19991001)5:10<2885::AID-CHEM2885>3.0.CO;2-8

Reference yield:

: 183378-05-4
trimethylsilyl ether of (1S,2S)-N-trifluoroacetamidonorpseudoephedrine

: 247256-58-2
(3R,5RS,1'S,2'S)-1-tert-Butyldiphenylsiloxy-3,7-dimethyl-3-(1'-phenyl-2'-trifluoroacetamido-1'-propoxy)-5-octanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / TfOH / CH₂Cl₂ / 5 h / -78 °C

2.1: O₃ / CH₂Cl₂; methanol / -78 °C

2.2: 95 percent / PPh₃ / 0.5 h / -78 °C

3.1: 96 percent / tetrahydrofuran; diethyl ether / 4 h / -78 - 20 °C

With trifluorormethanesulfonic acid; ozone; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1.1: Etherification / 2.1: Oxidation / 2.2: Reduction / 3.1: Grignard reaction;
DOI:10.1002/(SICI)1521-3765(19991001)5:10<2885::AID-CHEM2885>3.0.CO;2-8