1-(2-pyridinyl)-3-(3-pyridinyl)-1,3-propanedione

Base Information

• Chemical Name: 1-(2-pyridinyl)-3-(3-pyridinyl)-1,3-propanedione
• CAS No.: 1001014-78-3
• Molecular Formula: C₁₃H₁₀N₂O₂
• Molecular Weight: 226.235
• Mol file: 1001014-78-3.mol

Synonyms:1-(2-pyridyl)-3-(3-pyridyl)-1,3-propanedione

Chemical Property of 1-(2-pyridinyl)-3-(3-pyridinyl)-1,3-propanedione

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-(2-pyridinyl)-3-(3-pyridinyl)-1,3-propanedione

There total 1 articles about 1-(2-pyridinyl)-3-(3-pyridinyl)-1,3-propanedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-acetylpyridine (1122-62-9) + methyl 3-pyridinecarboxylate (93-60-7) → 1-(2-pyridyl)-3-(3-pyridyl)-1,3-propanedione (1001014-78-3)

Guidance literature:

With sodium methylate; In tetrahydrofuran; at 20 - 50 ℃; for 19.5h;

Reference yield:

1-(2-pyridyl)-3-(3-pyridyl)-1,3-propanedione (1001014-78-3) + 4-iodophenylhydrazine (13116-27-3) → 2-(1-(4-iodophenyl)-5-(pyridin-3-yl)-1H-pyrazol-3-yl)pyridine (1001014-79-4) + 3-(1-(4-iodophenyl)-5-(pyridin-2-yl)-1H-pyrazol-3-yl)pyridine (1001014-80-7)

Guidance literature:

1-(2-pyridyl)-3-(3-pyridyl)-1,3-propanedione; 4-iodophenylhydrazine; With acetic acid; at 70 ℃; for 1.5h;

With water; sodium hydrogencarbonate;

Reference yield:

1-(2-pyridyl)-3-(3-pyridyl)-1,3-propanedione (1001014-78-3) → 1-(4-(3-(pyridin-2-yl)-5-(pyridin-3-yl)-1H-pyrazol-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine bistrifluoroacetate

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 1.5 h / 70 °C

2: potassium phosphate / trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide / 1,4-dioxane / 18 h / 120 °C

With potassium phosphate; acetic acid; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; In 1,4-dioxane;

upstream raw materials:

2-acetylpyridine

methyl 3-pyridinecarboxylate

Downstream raw materials:

2-(1-(4-iodophenyl)-5-(pyridin-3-yl)-1H-pyrazol-3-yl)pyridine

3-(1-(4-iodophenyl)-5-(pyridin-2-yl)-1H-pyrazol-3-yl)pyridine

Refernces