4-Iodophenylhydrazine

Base Information

• Chemical Name: 4-Iodophenylhydrazine
• CAS No.: 13116-27-3
• Molecular Formula: C6H7 I N2
• Molecular Weight: 234.039
• Hs Code.: 29280000
• European Community (EC) Number: 626-382-4
• DSSTox Substance ID: DTXSID60351606
• Nikkaji Number: J1.237.726F
• Wikidata: Q72484372
• Mol file: 13116-27-3.mol

Synonyms:4-Iodophenylhydrazine;(4-iodophenyl)hydrazine;13116-27-3;1-(4-iodophenyl)hydrazine;(4-Iodo-phenyl)-hydrazine;(4-IODOPHENYL)HYDRAZINE HYDROIODIDE;MFCD00052688;4-iodo phenyl hydrazine;p-iodophenyl-hydrazine;4-Iodophenylhydrazine, 95%;Hydrazine, (4-iodophenyl)-;SCHEMBL1003203;DTXSID60351606;BBL020471;STK662474;AKOS005254837;PS-4488;BB 0249774;CS-0186076;FT-0618805;EN300-1262787;A806212;J-503329

Chemical Property of 4-Iodophenylhydrazine

Chemical Property:

• Appearance/Colour: White to orange-brown crystalline powder
• Vapor Pressure: 0.000856mmHg at 25°C
• Melting Point: 102-106 ºC
• Refractive Index: 1.74
• Boiling Point: 304.8°Cat760mmHg
• PKA: 4.91±0.20(Predicted)
• Flash Point: 138.1°C
• PSA: 38.05000
• Density: 1.981g/cm³
• LogP: 2.35010
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Sensitive.: Light Sensitive
• Water Solubility.: Insoluble in water.
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 233.96540
• Heavy Atom Count: 9
• Complexity: 79.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Iodophenylhydrazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-43-40-20/21/22
• Safety Statements: 26-45-36/37/39-24-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1NN)I

Technology Process of 4-Iodophenylhydrazine

There total 4 articles about 4-Iodophenylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

p-aminoiodobenzene (540-37-4) → 4-iodophenylhydrazine (13116-27-3)

Guidance literature:

p-aminoiodobenzene; With hydrogenchloride; sodium nitrite; In water; at -10 ℃; for 0.5h;

With hydrogenchloride; tin(II) chloride dihdyrate; In water; at -10 - 5 ℃; for 19.5h;

DOI:10.1039/c6cc09624g

Reference yield: 50.0%

stannous chloride (7772-99-8) + p-aminoiodobenzene (540-37-4) → 5-iodo-2,3,3-trimethyl-3H-indole (54136-25-3) + 4-iodophenylhydrazine (13116-27-3)

Guidance literature:

With hydrogenchloride; sodium nitrate; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; hexane; water; toluene;

Reference yield:

C6H5IN2O2 → 4-iodophenylhydrazine (13116-27-3)

Guidance literature:

With hydrogenchloride; tin(II) chloride dihdyrate; water; at 0 ℃; for 2.5h; Inert atmosphere;

DOI:10.1055/s-0030-1260082

upstream raw materials:

p-aminoiodobenzene

stannous chloride

Downstream raw materials:

piperonal-(4-iodo-phenylhydrazone)

(E)-1-benzylidene-2-(4-iodophenyl)hydrazine

acetone-(4-iodo-phenylhydrazone)

D-lyxo-[2]hexosulose-bis-(4-iodo-phenylhydrazone)

Refernces

• 1、 Kormos, Attila,Koehler, Christine,Fodor, Eszter A.,Rutkai, Zsófia R.,Martin, Madison E.,Mez?, Gábor,Lemke, Edward A.,Kele, Péter. "Bistetrazine-Cyanines as Double-Clicking Fluorogenic Two-Point Binder or Crosslinker Probes". . p. 8841 - 8847. Retrieved 2018.
• 2、 Chen, Jing,Winter, Rainer F.. "Studies on a vinyl ruthenium-modified squaraine dye: Multiple visible/near-infrared absorbance switching through dye- and substituent-based redox processes". . p. 10733 - 10741. Retrieved 2012.
• 3、 Ebaston, T. M.,Gellerman, Gary,Nakonechny, Faina,Patsenker, Leonid,Talalai, Efrosiniia. "Iodinated xanthene-cyanine NIR dyes as potential photosensitizers for antimicrobial photodynamic therapy". . . Retrieved 2021.