3'-(4-methanesulfonamidobenzyl)-6-bromo-2,2-dimethyl-2,3-dihydro-2'H-spiro[chromene-4,5'-[1,3]oxazolidin]-2'-one

Base Information

Chemical Name:3'-(4-methanesulfonamidobenzyl)-6-bromo-2,2-dimethyl-2,3-dihydro-2'H-spiro[chromene-4,5'-[1,3]oxazolidin]-2'-one
CAS No.:1283071-67-9
Molecular Formula:C₂₁H₂₃BrN₂O₅S
Molecular Weight:495.394
Hs Code.:

Synonyms:3'-(4-methanesulfonamidobenzyl)-6-bromo-2,2-dimethyl-2,3-dihydro-2'H-spiro[chromene-4,5'-[1,3]oxazolidin]-2'-one

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Chemical Property of 3'-(4-methanesulfonamidobenzyl)-6-bromo-2,2-dimethyl-2,3-dihydro-2'H-spiro[chromene-4,5'-[1,3]oxazolidin]-2'-one

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Technology Process of 3'-(4-methanesulfonamidobenzyl)-6-bromo-2,2-dimethyl-2,3-dihydro-2'H-spiro[chromene-4,5'-[1,3]oxazolidin]-2'-one

There total 5 articles about 3'-(4-methanesulfonamidobenzyl)-6-bromo-2,2-dimethyl-2,3-dihydro-2'H-spiro[chromene-4,5'-[1,3]oxazolidin]-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1283071-68-0
3'-(4-aminobenzyl)-6-bromo-2,2-dimethyl-2,3-dihydro-2'H-spiro[chromene-4,5'-[1,3]oxazolidin]-2'-one

: 124-63-0
methanesulfonyl chloride

: 1283071-67-9
3'-(4-methanesulfonamidobenzyl)-6-bromo-2,2-dimethyl-2,3-dihydro-2'H-spiro[chromene-4,5'-[1,3]oxazolidin]-2'-one

Guidance literature:: With pyridine; In 1,4-dioxane; at 0 ℃; for 1h; Reflux;
DOI:10.1016/j.ejmech.2011.01.003

Reference yield:

: 918151-01-6
6-bromo-3,4-dihydro-2,2-dimethyl-4-[(trimethylsilyl)oxy]-2H-1-benzopyran-4-carbonitrile

: 1283071-67-9
3'-(4-methanesulfonamidobenzyl)-6-bromo-2,2-dimethyl-2,3-dihydro-2'H-spiro[chromene-4,5'-[1,3]oxazolidin]-2'-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran

2.1: tetrahydrofuran / 1 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

3.2: 1 h / 0 - 20 °C / Inert atmosphere

4.1: iron(III) chloride; pyrographite; hydrazine hydrate / methanol / 60 °C / Reflux

5.1: pyridine / 1,4-dioxane / 1 h / 0 °C / Reflux

With pyridine; iron(III) chloride; lithium aluminium tetrahydride; sodium hydride; pyrographite; hydrazine hydrate; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.ejmech.2011.01.003

Reference yield:

: 6-bromo-2,2-dimethyl-3'-(4-nitrobenzyl)-2,3-dihydro-2'H-spiro[chromene-4,5'-[1,3]oxazolidin]-2'-one

: 1283071-67-9
3'-(4-methanesulfonamidobenzyl)-6-bromo-2,2-dimethyl-2,3-dihydro-2'H-spiro[chromene-4,5'-[1,3]oxazolidin]-2'-one

Guidance literature:: Multi-step reaction with 2 steps

1: iron(III) chloride; pyrographite; hydrazine hydrate / methanol / 60 °C / Reflux

2: pyridine / 1,4-dioxane / 1 h / 0 °C / Reflux

With pyridine; iron(III) chloride; pyrographite; hydrazine hydrate; In 1,4-dioxane; methanol;
DOI:10.1016/j.ejmech.2011.01.003