5,7-Bis-benzyloxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene-3-carboxylic acid methyl ester

Base Information

Chemical Name:5,7-Bis-benzyloxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene-3-carboxylic acid methyl ester
CAS No.:132018-14-5
Molecular Formula:C₃₁H₂₃NO₈
Molecular Weight:537.526
Hs Code.:
ChEMBL ID:CHEMBL352269
DSSTox Substance ID:DTXSID801129530
Nikkaji Number:J376.213K

Synonyms:CHEMBL352269;DTXSID801129530;BDBM50011423;5,7-Bis-benzyloxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene-3-carboxylic acid methyl ester;132018-14-5;Methyl 2-(4-nitrophenyl)-4-oxo-5,7-bis(phenylmethoxy)-4H-1-benzopyran-3-carboxylate

Suppliers and Price of 5,7-Bis-benzyloxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene-3-carboxylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5,7-Bis-benzyloxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene-3-carboxylic acid methyl ester

Chemical Property:

XLogP3:6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:9
Exact Mass:537.14236669
Heavy Atom Count:40
Complexity:924

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=C(OC2=C(C1=O)C(=CC(=C2)OCC3=CC=CC=C3)OCC4=CC=CC=C4)C5=CC=C(C=C5)[N+](=O)[O-]

Technology Process of 5,7-Bis-benzyloxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene-3-carboxylic acid methyl ester

There total 1 articles about 5,7-Bis-benzyloxy-2-(4-nitro-phenyl)-4-oxo-4H-chromene-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18065-05-9
1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone

: 132018-14-5
5,7-bis(benzyloxy)-3-(methoxycarbonyl)-2-(4-nitrophenyl)-4H-benzopyran-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium bis(trimethylsilyl)amide / 1.) a.) THF, -78 deg C, b.) -10 deg C, 2 h, 2.) a.) from -78 deg C to 25 deg C, 3-4 h, b.) RT, 4 h

2: 1.) Mg, CCl₄ / 1.) ethanol, 50 to 55 deg C, 5 to 6 h, 2.) benzene, reflux, 8 h

With tetrachloromethane; magnesium; lithium hexamethyldisilazane;
DOI:10.1021/jm00106a047

Reference yield:

: 132018-14-5
5,7-bis(benzyloxy)-3-(methoxycarbonyl)-2-(4-nitrophenyl)-4H-benzopyran-4-one

: 132018-33-8
2-(4-aminophenyl)-5,7-dihydroxy-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1 M tribromoborane / CH₂Cl₂ / 40 h / Ambient temperature

2: quinoline / 0.17 h / 180 - 185 °C

3: 91 percent / H₂ / 5percent Pd/C / dioxane / 8 h / 2068.6 Torr

With hydrogen; boron tribromide; palladium on activated charcoal; In 1,4-dioxane; quinoline; dichloromethane;
DOI:10.1021/jm00106a047