6-METHOXY-PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE

Base Information

• Chemical Name: 6-METHOXY-PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
• CAS No.: 855784-42-8
• Molecular Formula: C7H9 N3 O2
• Molecular Weight: 167.167
• Hs Code.: 2933399090
• Mol file: 855784-42-8.mol

Synonyms:6-METHOXY-PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE

Chemical Property of 6-METHOXY-PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE

Chemical Property:

• Melting Point: 155-156°C
• Refractive Index: 1.562
• PSA: 77.24000
• Density: 1.245g/cm³
• LogP: 0.78490

Purity/Quality:

98%Min ^*data from raw suppliers

6-Methoxy-pyridine-2-carboxylic acid hydrazide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-METHOXY-PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE

There total 2 articles about 6-METHOXY-PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-[(6-methoxypyridin-2-yl)carbonyl]hydrazinecarboxylate (1254073-75-0) → 6-methoxypyridin-2-carbohydrazide (855784-42-8)

Guidance literature:

tert-butyl 2-[(6-methoxypyridin-2-yl)carbonyl]hydrazinecarboxylate; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 5h; Inert atmosphere;

With ammonia; In methanol;

Reference yield:

→ 6-methoxypyridin-2-carbohydrazide (855784-42-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 60 ℃; for 4h; Inert atmosphere;

Reference yield: 46.0%

6-methoxypyridin-2-carbohydrazide (855784-42-8) + (1R,2S)-1-(5-chloropyrimidin-2-yl)-1-methoxypropane-2-sulfonamide + 1-aminobicyclo<1.1.1>pentane hydrochloride (22287-35-0) + 1,1'-Thiocarbonyldi-2(1H)-pyridone (102368-13-8) → (Z)-N’-(bicyclo[1.1.1]pentan-1-yl)-N-(((1R,2S)-1-(5-chloropyrimidin-2-yl)-1-methoxypropan-2-yl)sulfonyl)-2-(6-methoxypicolinoyl)hydrazinecarboximidamide

Guidance literature:

(1R,2S)-1-(5-chloropyrimidin-2-yl)-1-methoxypropane-2-sulfonamide; 1,1'-Thiocarbonyldi-2(1H)-pyridone; With caesium carbonate; In dichloromethane; at 23 ℃; for 1h;

1-aminobicyclo<1.1.1>pentane hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h;

6-methoxypyridin-2-carbohydrazide; With silver nitrate; In dichloromethane; for 19h;

upstream raw materials:

tert-butyl 2-[(6-methoxypyridin-2-yl)carbonyl]hydrazinecarboxylate

Downstream raw materials:

7-[(2,4-dichloro-3-fluorophenyl)carbonyl]-3-[6-(methyloxy)-2-pyridinyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

Refernces

• 1、 -. "1, 2, 4-TRIAZOLONE DERIVATIVE". Paragraph 0451; 0452; 0511; 0512. . Retrieved 2013/08/14.