ethyl (E)-3-(2-{3'-[1-(4-oxoadamantyl)]-4'-hydroxyphenyl}-5-pyrimidinyl)-2-propenoate

Base Information

Chemical Name:ethyl (E)-3-(2-{3'-[1-(4-oxoadamantyl)]-4'-hydroxyphenyl}-5-pyrimidinyl)-2-propenoate
CAS No.:1313053-22-3
Molecular Formula:C₂₅H₂₆N₂O₄
Molecular Weight:418.492
Hs Code.:

Synonyms:ethyl (E)-3-(2-{3'-[1-(4-oxoadamantyl)]-4'-hydroxyphenyl}-5-pyrimidinyl)-2-propenoate

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Chemical Property of ethyl (E)-3-(2-{3'-[1-(4-oxoadamantyl)]-4'-hydroxyphenyl}-5-pyrimidinyl)-2-propenoate

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Technology Process of ethyl (E)-3-(2-{3'-[1-(4-oxoadamantyl)]-4'-hydroxyphenyl}-5-pyrimidinyl)-2-propenoate

There total 9 articles about ethyl (E)-3-(2-{3'-[1-(4-oxoadamantyl)]-4'-hydroxyphenyl}-5-pyrimidinyl)-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: ethyleneglycol ketal of ethyl (E)-3-(2-{4'-benzyloxy-3'-[1-(4-oxoadamantyl)]phenyl}-5-pyrimidinyl)-2-propenoate

: 1313053-22-3
ethyl (E)-3-(2-{3'-[1-(4-oxoadamantyl)]-4'-hydroxyphenyl}-5-pyrimidinyl)-2-propenoate

Guidance literature:: ethyleneglycol ketal of ethyl (E)-3-(2-{4'-benzyloxy-3'-[1-(4-oxoadamantyl)]phenyl}-5-pyrimidinyl)-2-propenoate; With boron tribromide; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere;

With water; In dichloromethane; Inert atmosphere;

Reference yield:

: 140-88-5,9003-32-1
ethyl acrylate

: 1313053-22-3
ethyl (E)-3-(2-{3'-[1-(4-oxoadamantyl)]-4'-hydroxyphenyl}-5-pyrimidinyl)-2-propenoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3.5 h / 115 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 90 °C

3.1: boron tribromide / dichloromethane / 2 h / -78 °C / Inert atmosphere

3.2: Inert atmosphere

With boron tribromide; sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; tris-(o-tolyl)phosphine; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1313053-26-7
ethyleneglycol ketal of 4-benzyloxy-3-[1-(4-oxoadamantyl)]phenylboronic acid

: 1313053-22-3
ethyl (E)-3-(2-{3'-[1-(4-oxoadamantyl)]-4'-hydroxyphenyl}-5-pyrimidinyl)-2-propenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 90 °C

2.1: boron tribromide / dichloromethane / 2 h / -78 °C / Inert atmosphere

2.2: Inert atmosphere

With boron tribromide; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water;