(2R,5R)-3,6-Diethoxy-2-[2-(4-heptyloxy-phenyl)-ethyl]-5-isopropyl-2,5-dihydro-pyrazine

Base Information

Chemical Name:(2R,5R)-3,6-Diethoxy-2-[2-(4-heptyloxy-phenyl)-ethyl]-5-isopropyl-2,5-dihydro-pyrazine
CAS No.:500760-51-0
Molecular Formula:C₂₆H₄₂N₂O₃
Molecular Weight:430.631
Hs Code.:

Synonyms:(2R,5R)-3,6-Diethoxy-2-[2-(4-heptyloxy-phenyl)-ethyl]-5-isopropyl-2,5-dihydro-pyrazine

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Chemical Property of (2R,5R)-3,6-Diethoxy-2-[2-(4-heptyloxy-phenyl)-ethyl]-5-isopropyl-2,5-dihydro-pyrazine

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Technology Process of (2R,5R)-3,6-Diethoxy-2-[2-(4-heptyloxy-phenyl)-ethyl]-5-isopropyl-2,5-dihydro-pyrazine

There total 1 articles about (2R,5R)-3,6-Diethoxy-2-[2-(4-heptyloxy-phenyl)-ethyl]-5-isopropyl-2,5-dihydro-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 110117-71-0
(2R)-3,6-diethoxy-2-isopropyl-2,5-dihydropyrazine

: 162358-40-9
2-(4-heptyloxyphenyl)ethyl iodide

: 500760-51-0
(2R,5R)-3,6-Diethoxy-2-[2-(4-heptyloxy-phenyl)-ethyl]-5-isopropyl-2,5-dihydro-pyrazine

Guidance literature:: (2R)-3,6-diethoxy-2-isopropyl-2,5-dihydropyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃;

2-(4-heptyloxyphenyl)ethyl iodide; In tetrahydrofuran; at -78 - 0 ℃;
DOI:10.1016/S0040-4039(02)01925-1

Reference yield: 65.0%

: 500760-51-0
(2R,5R)-3,6-Diethoxy-2-[2-(4-heptyloxy-phenyl)-ethyl]-5-isopropyl-2,5-dihydro-pyrazine

: 74-88-4
methyl iodide

: 500760-45-2
(2R,5R)-3,6-Diethoxy-2-[2-(4-heptyloxy-phenyl)-ethyl]-5-isopropyl-2-methyl-2,5-dihydro-pyrazine

Guidance literature:: (2R,5R)-3,6-Diethoxy-2-[2-(4-heptyloxy-phenyl)-ethyl]-5-isopropyl-2,5-dihydro-pyrazine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -65 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at -78 - 0 ℃; for 5.5h;
DOI:10.1016/S0040-4039(02)01925-1

Reference yield:

: 500760-51-0
(2R,5R)-3,6-Diethoxy-2-[2-(4-heptyloxy-phenyl)-ethyl]-5-isopropyl-2,5-dihydro-pyrazine

: (R)-AFD

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 - -65 °C

1.2: 65 percent / tetrahydrofuran / 5.5 h / -78 - 0 °C

2.1: aq. HCl / dioxane / 16 h / 20 °C

2.2: LiAlH₄ / tetrahydrofuran / 2 h / 65 °C

3.1: 85 percent / CH₂Cl₂; tetrahydrofuran

4.1: tetrazole / tetrahydrofuran / 2 h / 20 °C

4.2: 85 percent / aq. H₂O₂ / tetrahydrofuran / 1 h / 20 °C

5.1: hydrogen / Pd/C / methanol / 1 h / 20 °C / 750.06 Torr

5.2: 88 percent / conc. HCl / ethyl acetate / 16 h / 20 °C

With 1H-tetrazole; hydrogenchloride; n-butyllithium; hydrogen; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane;
DOI:10.1016/S0040-4039(02)01925-1