4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone

Base Information

• Chemical Name: 4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone
• CAS No.: 955360-35-7
• Molecular Formula: C₃₃H₃₇Cl₂N₃O₂
• Molecular Weight: 578.582
• Mol file: 955360-35-7.mol

Synonyms:4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone

Chemical Property of 4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone

There total 9 articles about 4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-hydroxyphenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone (955360-34-6) + 1.3-chlorobromopropane (109-70-6) → 4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone (955360-35-7)

Guidance literature:

With potassium carbonate; In butanone; at 20 ℃; for 25 - 41h; Product distribution / selectivity; Heating / reflux;

Reference yield:

4-(4-methoxyphenyl)butan-1-ol (52244-70-9,239474-80-7) → 4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone (955360-35-7)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / diethyl ether / 4 h / 0 °C / Inert atmosphere

2: potassium carbonate / butanone / 24 h / Reflux

3: boron tribromide / dichloromethane / 18 h / -60 - 20 °C / Inert atmosphere

4: potassium carbonate / butanone / 41 h / Reflux; Inert atmosphere

With boron tribromide; potassium carbonate; triethylamine; In diethyl ether; dichloromethane; butanone;

DOI:10.1021/jm1013874

Reference yield:

4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-methoxyphenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone (955360-33-5) → 4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-(3-chloropropoxy)phenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone (955360-35-7)

Guidance literature:

Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 18 h / -60 - 20 °C / Inert atmosphere

2: potassium carbonate / butanone / 41 h / Reflux; Inert atmosphere

With boron tribromide; potassium carbonate; In dichloromethane; butanone;

DOI:10.1021/jm1013874

upstream raw materials:

4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-hydroxyphenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone

1.3-chlorobromopropane

4-[(4-chlorophenyl)methyl]-2-[((2R)-1-{4-[4-methoxyphenyl]butyl}-2-pyrrolidinyl)methyl]-1(2H)-phthalazinone

4-(4-methoxyphenyl)butan-1-ol

Downstream raw materials:

GSK-1004723