trans-1-[8-chloro-1-(4-phenyl-cyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulen-5-yl]-ethanone

Base Information

Chemical Name:trans-1-[8-chloro-1-(4-phenyl-cyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulen-5-yl]-ethanone
CAS No.:1337965-58-8
Molecular Formula:C₂₄H₂₅ClN₄O
Molecular Weight:420.942
Hs Code.:

Synonyms:trans-1-[8-chloro-1-(4-phenyl-cyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulen-5-yl]-ethanone

Suppliers and Price of trans-1-[8-chloro-1-(4-phenyl-cyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulen-5-yl]-ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-1-[8-chloro-1-(4-phenyl-cyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulen-5-yl]-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-1-[8-chloro-1-(4-phenyl-cyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulen-5-yl]-ethanone

There total 12 articles about trans-1-[8-chloro-1-(4-phenyl-cyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulen-5-yl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: trans-8-chloro-1-(4-phenyl-cyclohexyl)-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulene hydrochloride

: 75-36-5
acetyl chloride

: 1337965-58-8
trans-1-[8-chloro-1-(4-phenyl-cyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulen-5-yl]-ethanone

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 19h;

Reference yield:

: 50608-35-0
(5-chloro-2-nitrobenzylamino)acetic acid ethyl ester

: 1337965-58-8
trans-1-[8-chloro-1-(4-phenyl-cyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulen-5-yl]-ethanone

Guidance literature:: Multi-step reaction with 7 steps

1: dmap / dichloromethane / 18 h / 0 - 20 °C

2: hydrogen; zinc dibromide / palladium 10% on activated carbon / ethyl acetate / 48 h / 760.05 Torr

3: potassium tert-butylate / tetrahydrofuran / 3 h / 5 - 20 °C

4: Lawessons reagent / tetrahydrofuran / 3 h / Reflux

5: butan-1-ol / Reflux

6: hydrogenchloride / 50 °C

7: triethylamine / dichloromethane / 19 h / 20 °C

With Lawessons reagent; hydrogenchloride; dmap; potassium tert-butylate; hydrogen; triethylamine; zinc dibromide; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; butan-1-ol;

Reference yield:

: 1226807-98-2
[tert-butoxycarbonyl-(5-chloro-2-nitrobenzyl)amino]acetic acid ethyl ester

: 1337965-58-8
trans-1-[8-chloro-1-(4-phenyl-cyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulen-5-yl]-ethanone

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen; zinc dibromide / palladium 10% on activated carbon / ethyl acetate / 48 h / 760.05 Torr

2: potassium tert-butylate / tetrahydrofuran / 3 h / 5 - 20 °C

3: Lawessons reagent / tetrahydrofuran / 3 h / Reflux

4: butan-1-ol / Reflux

5: hydrogenchloride / 50 °C

6: triethylamine / dichloromethane / 19 h / 20 °C

With Lawessons reagent; hydrogenchloride; potassium tert-butylate; hydrogen; triethylamine; zinc dibromide; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate; butan-1-ol;