Kynurenic acid, 3-chloro- (5CI)

Base Information

• Chemical Name: Kynurenic acid, 3-chloro- (5CI)
• CAS No.: 855634-17-2
• Molecular Formula: C10H6 Cl N O3
• Molecular Weight: 223.616
• Mol file: 855634-17-2.mol

Synonyms:Kynurenicacid, 3-chloro- (5CI)

Chemical Property of Kynurenic acid, 3-chloro- (5CI)

Chemical Property:

• PSA: 70.16000
• LogP: 1.87970

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Kynurenic acid, 3-chloro- (5CI)

There total 2 articles about Kynurenic acid, 3-chloro- (5CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-hydroxyquinoline-2-carboxylate (24782-43-2) → 3-chloro-4-hydroxy-quinoline-2-carboxylic acid (855634-17-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; acetic acid anhydride; iodine; SO₂Cl₂

2: aqueous NaOH

With sodium hydroxide; sulfuryl dichloride; iodine; acetic anhydride; acetic acid;

DOI:10.1021/ja01216a044

Reference yield:

3-chloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester (408327-43-5,16377-66-5) → 3-chloro-4-hydroxy-quinoline-2-carboxylic acid (855634-17-2)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01216a044

Reference yield:

3-chloro-4-hydroxy-quinoline-2-carboxylic acid (855634-17-2) → (3-chloro-[4]quinolyl)-phenyl-amine

Guidance literature:

Multi-step reaction with 3 steps

1: diphenyl ether; biphenyl / 180 °C

2: phosphoryl chloride

3: 150 - 160 °C

With diphenylether; biphenyl; trichlorophosphate;

DOI:10.1021/ja01216a044

upstream raw materials:

3-chloro-4-hydroxy-quinoline-2-carboxylic acid ethyl ester

ethyl 4-hydroxyquinoline-2-carboxylate