methyl 5-(benzoyloxy)-2-{1-[(benzyloxy)carbonyl]piperazin-2-yl}-6-hydroxypyrimidine-4-carboxylate

Base Information

Chemical Name:methyl 5-(benzoyloxy)-2-{1-[(benzyloxy)carbonyl]piperazin-2-yl}-6-hydroxypyrimidine-4-carboxylate
CAS No.:940868-25-7
Molecular Formula:C₂₅H₂₄N₄O₇
Molecular Weight:492.488
Hs Code.:

Synonyms:methyl 5-(benzoyloxy)-2-{1-[(benzyloxy)carbonyl]piperazin-2-yl}-6-hydroxypyrimidine-4-carboxylate

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Chemical Property of methyl 5-(benzoyloxy)-2-{1-[(benzyloxy)carbonyl]piperazin-2-yl}-6-hydroxypyrimidine-4-carboxylate

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Technology Process of methyl 5-(benzoyloxy)-2-{1-[(benzyloxy)carbonyl]piperazin-2-yl}-6-hydroxypyrimidine-4-carboxylate

There total 7 articles about methyl 5-(benzoyloxy)-2-{1-[(benzyloxy)carbonyl]piperazin-2-yl}-6-hydroxypyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 519032-09-8
1-benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]-piperazine-1,4-dicarboxylate

: 940868-25-7
methyl 5-(benzoyloxy)-2-{1-[(benzyloxy)carbonyl]piperazin-2-yl}-6-hydroxypyrimidine-4-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm070027u

Reference yield:

: 955016-62-3
1-benzyl 4-(tert-butyl) 2-cyanopiperazine-1,4-dicarboxylate

: 940868-25-7
methyl 5-(benzoyloxy)-2-{1-[(benzyloxy)carbonyl]piperazin-2-yl}-6-hydroxypyrimidine-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: NH₂OH / methanol / 60 °C

2: CHCl₃ / 60 °C

3: xylene / 24 h / Heating

4: pyridine / 20 °C

5: trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

With pyridine; hydroxylamine; trifluoroacetic acid; In methanol; dichloromethane; chloroform; xylene;
DOI:10.1021/jm070027u

Reference yield:

: 955016-61-2
1-benzyl 4-tert-butyl 3-(aminocarbonyl)piperazine-1,4-dicarboxylate

: 940868-25-7
methyl 5-(benzoyloxy)-2-{1-[(benzyloxy)carbonyl]piperazin-2-yl}-6-hydroxypyrimidine-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N; trifluoroacetic anhydride / CH₂Cl₂ / 3.5 h / 20 °C

2: NH₂OH / methanol / 60 °C

3: CHCl₃ / 60 °C

4: xylene / 24 h / Heating

5: pyridine / 20 °C

6: trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

With pyridine; hydroxylamine; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; In methanol; dichloromethane; chloroform; xylene;
DOI:10.1021/jm070027u