1-benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]-piperazine-1,4-dicarboxylate

Base Information

Chemical Name:1-benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]-piperazine-1,4-dicarboxylate
CAS No.:519032-09-8
Molecular Formula:C₃₀H₃₂N₄O₉
Molecular Weight:592.605
Hs Code.:

Synonyms:1-benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]-piperazine-1,4-dicarboxylate

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Chemical Property of 1-benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]-piperazine-1,4-dicarboxylate

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Technology Process of 1-benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]-piperazine-1,4-dicarboxylate

There total 6 articles about 1-benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]-piperazine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(4,5-dihydroxy-6-methoxycarbonyl-pyrimidin-2-yl)-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

: 93-97-0
benzoic acid anhydride

: 519032-09-8
1-benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]-piperazine-1,4-dicarboxylate

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1021/jm070027u

Reference yield:

: 955016-62-3
1-benzyl 4-(tert-butyl) 2-cyanopiperazine-1,4-dicarboxylate

: 519032-09-8
1-benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]-piperazine-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: NH₂OH / methanol / 60 °C

2: CHCl₃ / 60 °C

3: xylene / 24 h / Heating

4: pyridine / 20 °C

With pyridine; hydroxylamine; In methanol; chloroform; xylene;
DOI:10.1021/jm070027u

Reference yield:

: 955016-61-2
1-benzyl 4-tert-butyl 3-(aminocarbonyl)piperazine-1,4-dicarboxylate

: 519032-09-8
1-benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]-piperazine-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N; trifluoroacetic anhydride / CH₂Cl₂ / 3.5 h / 20 °C

2: NH₂OH / methanol / 60 °C

3: CHCl₃ / 60 °C

4: xylene / 24 h / Heating

5: pyridine / 20 °C

With pyridine; hydroxylamine; triethylamine; trifluoroacetic anhydride; In methanol; dichloromethane; chloroform; xylene;
DOI:10.1021/jm070027u