(15S)-(3Z,7E,11E)-1-(2-bromo-4,4-dimethyl-1-cyclohexenyl)-4-tert-butyldimethylsiloxy-15,16-oxido-3,8,12,16-tetramethyl-3,7,11-pentadecatriene

Base Information

Chemical Name:(15S)-(3Z,7E,11E)-1-(2-bromo-4,4-dimethyl-1-cyclohexenyl)-4-tert-butyldimethylsiloxy-15,16-oxido-3,8,12,16-tetramethyl-3,7,11-pentadecatriene
CAS No.:251980-59-3
Molecular Formula:C₃₅H₆₁BrO₂Si
Molecular Weight:621.858
Hs Code.:

Synonyms:(15S)-(3Z,7E,11E)-1-(2-bromo-4,4-dimethyl-1-cyclohexenyl)-4-tert-butyldimethylsiloxy-15,16-oxido-3,8,12,16-tetramethyl-3,7,11-pentadecatriene

Suppliers and Price of (15S)-(3Z,7E,11E)-1-(2-bromo-4,4-dimethyl-1-cyclohexenyl)-4-tert-butyldimethylsiloxy-15,16-oxido-3,8,12,16-tetramethyl-3,7,11-pentadecatriene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (15S)-(3Z,7E,11E)-1-(2-bromo-4,4-dimethyl-1-cyclohexenyl)-4-tert-butyldimethylsiloxy-15,16-oxido-3,8,12,16-tetramethyl-3,7,11-pentadecatriene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (15S)-(3Z,7E,11E)-1-(2-bromo-4,4-dimethyl-1-cyclohexenyl)-4-tert-butyldimethylsiloxy-15,16-oxido-3,8,12,16-tetramethyl-3,7,11-pentadecatriene

There total 5 articles about (15S)-(3Z,7E,11E)-1-(2-bromo-4,4-dimethyl-1-cyclohexenyl)-4-tert-butyldimethylsiloxy-15,16-oxido-3,8,12,16-tetramethyl-3,7,11-pentadecatriene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 557-93-7
2-bromoprop-1-ene

: 181776-75-0
(S,4E,8E)-1-(-tert-butyldimethylsilyl)-11-(3,3-dimethyloxirane-2-yl)-5,9-dimethylundeca-4,8-dien-1-one

: 251980-58-2
2-bromo-1-(bromomethyl)-4,4-dimethylcyclohex-1-ene

: 251980-59-3
(15S)-(3Z,7E,11E)-1-(2-bromo-4,4-dimethyl-1-cyclohexenyl)-4-tert-butyldimethylsiloxy-15,16-oxido-3,8,12,16-tetramethyl-3,7,11-pentadecatriene

Guidance literature:: Multistep reaction;
DOI:10.1021/ja992411p

Reference yield:

: 2979-19-3
3,3-dimethylcyclohexanone

: 251980-59-3
(15S)-(3Z,7E,11E)-1-(2-bromo-4,4-dimethyl-1-cyclohexenyl)-4-tert-butyldimethylsiloxy-15,16-oxido-3,8,12,16-tetramethyl-3,7,11-pentadecatriene

Guidance literature:: Multi-step reaction with 5 steps

1.1: PBr₃ / CHCl₃ / 0.5 h / 70 °C

1.2: CHCl₃ / 1.5 h / 70 °C

2.1: DIBAL / diethyl ether; toluene / 1 h / 23 °C

3.1: Et₃N / tetrahydrofuran / 0.5 h / -40 °C

4.1: 92 percent / LiBr / tetrahydrofuran / 1 h / 0 °C

5.1: 84 percent

With phosphorus tribromide; diisobutylaluminium hydride; triethylamine; lithium bromide; In tetrahydrofuran; diethyl ether; chloroform; toluene; 1.1: phosphorylation / 1.2: Formylation / 2.1: Reduction / 3.1: mesylation / 4.1: Bromination;
DOI:10.1021/ja992411p

Reference yield:

: 251980-66-2
2-bromo-1-hydroxymethyl-4,4-dimethyl-1-cyclohexene

: 251980-59-3
(15S)-(3Z,7E,11E)-1-(2-bromo-4,4-dimethyl-1-cyclohexenyl)-4-tert-butyldimethylsiloxy-15,16-oxido-3,8,12,16-tetramethyl-3,7,11-pentadecatriene

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 0.5 h / -40 °C

2: 92 percent / LiBr / tetrahydrofuran / 1 h / 0 °C

3: 84 percent

With triethylamine; lithium bromide; In tetrahydrofuran; 1: mesylation / 2: Bromination;
DOI:10.1021/ja992411p