5-amino-8-cyclohexylmethoxy-2,3,4,5-tetrahydro-benzo[b]oxepine-7-carboxylic acid amide

Base Information

Chemical Name:5-amino-8-cyclohexylmethoxy-2,3,4,5-tetrahydro-benzo[b]oxepine-7-carboxylic acid amide
CAS No.:307312-97-6
Molecular Formula:C₁₈H₂₆N₂O₃
Molecular Weight:318.416
Hs Code.:

5-amino-8-cyclohexylmethoxy-2,3,4,5-tetrahydro-benzo[<i>b</i>]oxepine-7-carboxylic acid amide

Synonyms:5-amino-8-cyclohexylmethoxy-2,3,4,5-tetrahydro-benzo[b]oxepine-7-carboxylic acid amide

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Chemical Property of 5-amino-8-cyclohexylmethoxy-2,3,4,5-tetrahydro-benzo[b]oxepine-7-carboxylic acid amide

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Technology Process of 5-amino-8-cyclohexylmethoxy-2,3,4,5-tetrahydro-benzo[b]oxepine-7-carboxylic acid amide

There total 7 articles about 5-amino-8-cyclohexylmethoxy-2,3,4,5-tetrahydro-benzo[b]oxepine-7-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 307312-96-5
5-azido-8-cyclohexylmethoxy-2,3,4,5-tetrahydro-benzo[b]oxepine-7-carboxylic acid amide

: 307312-97-6
5-amino-8-cyclohexylmethoxy-2,3,4,5-tetrahydro-benzo[b]oxepine-7-carboxylic acid amide

Guidance literature:: With hydrogen; 10percent Pd/C; In ethyl acetate;
DOI:10.1021/jm0003337

Reference yield:

: 3147-45-3
2,4-dihydroxybenzamide

: 307312-97-6
5-amino-8-cyclohexylmethoxy-2,3,4,5-tetrahydro-benzo[b]oxepine-7-carboxylic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1: Cs₂CO₃ / dimethylformamide

2: Cs₂CO₃ / dimethylformamide

3: LiOH / tetrahydrofuran

4: PPA / 80 °C

5: NaBH₄ / methanol

6: (C₆H₅O)2P(O)N₃; DBU / toluene

7: 98 percent / H₂ / 10percent Pd/C / ethyl acetate

With lithium hydroxide; sodium tetrahydroborate; diphenyl phosphoryl azide; hydrogen; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 10percent Pd/C; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene; 1: Alkylation / 2: Alkylation / 3: Hydrolysis / 4: Cyclization / 5: Reduction / 6: Substitution / 7: Catalytic hydrogenation;
DOI:10.1021/jm0003337

Reference yield:

: 268741-81-7
4-(4-carbamoyl-3-hydroxy-phenoxy)-butyric acid ethyl ester

: 307312-97-6
5-amino-8-cyclohexylmethoxy-2,3,4,5-tetrahydro-benzo[b]oxepine-7-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1: Cs₂CO₃ / dimethylformamide

2: LiOH / tetrahydrofuran

3: PPA / 80 °C

4: NaBH₄ / methanol

5: (C₆H₅O)2P(O)N₃; DBU / toluene

6: 98 percent / H₂ / 10percent Pd/C / ethyl acetate

With lithium hydroxide; sodium tetrahydroborate; diphenyl phosphoryl azide; hydrogen; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 10percent Pd/C; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; toluene; 1: Alkylation / 2: Hydrolysis / 3: Cyclization / 4: Reduction / 5: Substitution / 6: Catalytic hydrogenation;
DOI:10.1021/jm0003337