3147-45-3

Basic information

• Product Name: 2,4-Dihydroxybenzamide
• Synonyms: B-RESORCYL AMIDE;2,4-DIHYDROXY BENZOYLAMINE;2,4-DIHYDROXYBENZAMIDE;4-HYDROXY SALICYLAMIDE;P-Hydroxysalicylamide;2,4-Dihydroxybenzamide(P-Hydroxysalicylamide);2,4-dihydroxy-benzamid;p-hydroxysaliamide
• CAS NO: 3147-45-3
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.14
• EINECS: 221-567-2
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 3147-45-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 228 °C
• Boiling Point: 455.8 °C at 760 mmHg
• Flash Point: 229.4 °C
• Appearance: /
• Density: 1.458 g/cm³
• Vapor Pressure: 6.32E-09mmHg at 25°C
• Refractive Index: 1.664
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 8.15±0.10(Predicted)
• CAS DataBase Reference: 2,4-Dihydroxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dihydroxybenzamide(3147-45-3)
• EPA Substance Registry System: 2,4-Dihydroxybenzamide(3147-45-3)

Safety Data

• Hazardous Substances Data: 3147-45-3(Hazardous Substances Data)

Usage

Uses

2,4-Dihydroxybenzamide is a specific inhibitor of glutathione reductase.

InChI:InChI=1/C7H7NO3/c8-7(11)5-2-1-4(9)3-6(5)10/h1-3,9-10H,(H2,8,11)

Upstream product

• 57-13-6 urea 
• 108-46-3 recorcinol 
• 556-89-8 nitrourea 
• 590-28-3 potassium cyanate 
• 598-50-5 N-Methylurea 
• 33617-59-3 1,3-dihydroxy-4-dihydroxymethyl benzene 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 50740-12-0 2,4-diacetoxybenzoyl chloride 
• 51-01-4 2,4-bis(acetyloxy)benzoic acid 
• 89-86-1 4-hydroxysalicylic acid 
• 7664-93-9 sulfuric acid 
• 195723-39-8 2,4-diacetoxybenzamide 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 

Downstream Products

• 67828-45-9 5-chloro-2,4-dihydroxy-benzoic acid amide 

Relevant articles and documents

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FeIII-catalyzed synthesis of primary amides from aldehydes

A direct synthetic route for the transformation of aldehydes into primary amides in the presence of catalytic amounts of FeCl3 in water is described. A direct synthetic route for the transformation of aldehydes into primary amides in the presence of catalytic amounts of FeCl3 in water is described. Copyright

Novel Enzymatic De-esterification Studies on Substituted Polyacetoxybenzamides

The regioselective capabilities of porcine pancreatic lipase in tetrahydrofuran and Candida rugosa lipase in diisopropyl ether have been investigated for selective deacetylation of peracetates of primary, secondary and tertiary amides of 2-hydroxy-, 2,4-dihydroxy-, 2,5-dihydroxy-, 3,5-dihydroxy- and 3,4,5-trihydroxybenzoic acids. The lipases exhibit random selectivity for the deacetylation of ortho-, meta- and para-acetoxy functions of di/triacetoxybenzamides leading to the formation of the corresponding partially and/or completely deacetylated benzamides. The amide group of all substrates under investigation remains inert to enzymatic hydrolysis. The results of deesterification are in good agreement with our earlier proposed mechanism of action of porcine pancreatic lipase on diaryl or aryl alkyl ketones in organic solvents.