1-((2,4-dichloro-phenyl)-{4-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrrol-3-yl}-methyl)-1H-imidazole

Base Information

• Chemical Name: 1-((2,4-dichloro-phenyl)-{4-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrrol-3-yl}-methyl)-1H-imidazole
• CAS No.: 444808-51-9
• Molecular Formula: C₂₅H₂₃Cl₂N₃O₂
• Molecular Weight: 468.383

Synonyms:1-((2,4-dichloro-phenyl)-{4-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrrol-3-yl}-methyl)-1H-imidazole

Chemical Property of 1-((2,4-dichloro-phenyl)-{4-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrrol-3-yl}-methyl)-1H-imidazole

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Technology Process of 1-((2,4-dichloro-phenyl)-{4-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrrol-3-yl}-methyl)-1H-imidazole

There total 5 articles about 1-((2,4-dichloro-phenyl)-{4-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrrol-3-yl}-methyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

1,1'-carbonyldiimidazole (530-62-1) + (2,4-dichloro-phenyl)-{4-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrrol-3-yl}-methanol (444808-47-3) → 1-((2,4-dichloro-phenyl)-{4-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrrol-3-yl}-methyl)-1H-imidazole (444808-51-9)

Guidance literature:

In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1021/jm011087h

Reference yield:

4-(tetrahydropyran-2-yloxy)benzaldehyde (74189-56-3) → 1-((2,4-dichloro-phenyl)-{4-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrrol-3-yl}-methyl)-1H-imidazole (444808-51-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 52 percent / Ba(OH)2*8H₂O / methanol / 1 h / 50 °C

2: 44 percent / NaH / dimethylsulfoxide; diethyl ether / 1 h / 20 °C

3: 100 percent / NaBH₄ / tetrahydrofuran; H₂O / 24 h / Heating

4: 37 percent / acetonitrile / 0.5 h / 20 °C

With barium dihydroxide; sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; methanol; diethyl ether; water; dimethyl sulfoxide; acetonitrile;

DOI:10.1021/jm011087h

Reference yield:

1-(2,4-dichlorophenyl)ethan-1-one (2234-16-4) → 1-((2,4-dichloro-phenyl)-{4-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrrol-3-yl}-methyl)-1H-imidazole (444808-51-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 52 percent / Ba(OH)2*8H₂O / methanol / 1 h / 50 °C

2: 44 percent / NaH / dimethylsulfoxide; diethyl ether / 1 h / 20 °C

3: 100 percent / NaBH₄ / tetrahydrofuran; H₂O / 24 h / Heating

4: 37 percent / acetonitrile / 0.5 h / 20 °C

With barium dihydroxide; sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; methanol; diethyl ether; water; dimethyl sulfoxide; acetonitrile;

DOI:10.1021/jm011087h

upstream raw materials:

1,1'-carbonyldiimidazole

(2,4-dichloro-phenyl)-{4-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-1H-pyrrol-3-yl}-methanol

4-(tetrahydropyran-2-yloxy)benzaldehyde

1-(2,4-dichlorophenyl)ethan-1-one

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