(1'S,2S,3S,3aS,4S)-2-(2'-tert-butyldiphenylsiloxy-1'-methanesulfonyloxyethyl)-4-tert-butoxy-3-tert-butyldiphenylsiloxymethyl-pyrrolidino[1,2-b]isoxazolidine

Base Information

Chemical Name:(1'S,2S,3S,3aS,4S)-2-(2'-tert-butyldiphenylsiloxy-1'-methanesulfonyloxyethyl)-4-tert-butoxy-3-tert-butyldiphenylsiloxymethyl-pyrrolidino[1,2-b]isoxazolidine
CAS No.:909531-15-3
Molecular Formula:C₄₆H₆₃NO₇SSi₂
Molecular Weight:830.246
Hs Code.:

(1'S,2S,3S,3aS,4S)-2-(2'-tert-butyldiphenylsiloxy-1'-methanesulfonyloxyethyl)-4-tert-butoxy-3-tert-butyldiphenylsiloxymethyl-pyrrolidino[1,2-b]isoxazolidine

Synonyms:(1'S,2S,3S,3aS,4S)-2-(2'-tert-butyldiphenylsiloxy-1'-methanesulfonyloxyethyl)-4-tert-butoxy-3-tert-butyldiphenylsiloxymethyl-pyrrolidino[1,2-b]isoxazolidine

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Chemical Property of (1'S,2S,3S,3aS,4S)-2-(2'-tert-butyldiphenylsiloxy-1'-methanesulfonyloxyethyl)-4-tert-butoxy-3-tert-butyldiphenylsiloxymethyl-pyrrolidino[1,2-b]isoxazolidine

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Technology Process of (1'S,2S,3S,3aS,4S)-2-(2'-tert-butyldiphenylsiloxy-1'-methanesulfonyloxyethyl)-4-tert-butoxy-3-tert-butyldiphenylsiloxymethyl-pyrrolidino[1,2-b]isoxazolidine

There total 3 articles about (1'S,2S,3S,3aS,4S)-2-(2'-tert-butyldiphenylsiloxy-1'-methanesulfonyloxyethyl)-4-tert-butoxy-3-tert-butyldiphenylsiloxymethyl-pyrrolidino[1,2-b]isoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 909531-07-3
(1'S,2S,3S,3aS,4S)-4-tert-butoxy-2-(1',2'-tert-butyldiphenylsiloxy-1'-hydroxyethyl)-3-tert-butyldiphenylsiloxymethyl-pyrrolidino[1,2-b]isoxazolidine

: 124-63-0
methanesulfonyl chloride

: 909531-15-3
(1'S,2S,3S,3aS,4S)-2-(2'-tert-butyldiphenylsiloxy-1'-methanesulfonyloxyethyl)-4-tert-butoxy-3-tert-butyldiphenylsiloxymethyl-pyrrolidino[1,2-b]isoxazolidine

Guidance literature:: With triethylamine; In dichloromethane; at -5 - 20 ℃; for 2h;
DOI:10.1016/j.carres.2006.05.003

Reference yield:

: 901120-03-4
(1aS,2R,4aR,4bS,5S)-5-tert-butoxy-2-formyl-4-oxo-pyrrolidino[1,2-b]isoxazolidino[4,5-c]tetrahydrofuran

: 909531-15-3
(1'S,2S,3S,3aS,4S)-2-(2'-tert-butyldiphenylsiloxy-1'-methanesulfonyloxyethyl)-4-tert-butoxy-3-tert-butyldiphenylsiloxymethyl-pyrrolidino[1,2-b]isoxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: LiBH₄ / tetrahydrofuran / 24 h / 20 °C

2: 0.13 g / Et₃N; DMAP / 27 h

3: 89 percent / Et₃N / CH₂Cl₂ / 2 h / -5 - 20 °C

With dmap; lithium borohydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.carres.2006.05.003

Reference yield:

: 909531-00-6
(1'S,2S,3S,3aS,4S)-4-tert-butoxy-2-(1',2'-dihydroxyethyl)-3-hydroxymethyl-pyrrolidino[1,2-b]isoxazolidine

: 909531-15-3
(1'S,2S,3S,3aS,4S)-2-(2'-tert-butyldiphenylsiloxy-1'-methanesulfonyloxyethyl)-4-tert-butoxy-3-tert-butyldiphenylsiloxymethyl-pyrrolidino[1,2-b]isoxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 0.13 g / Et₃N; DMAP / 27 h

2: 89 percent / Et₃N / CH₂Cl₂ / 2 h / -5 - 20 °C

With dmap; triethylamine; In dichloromethane;
DOI:10.1016/j.carres.2006.05.003