4-{2-[1-(3-amino-propylcarbamoyl)ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

Base Information

Chemical Name:4-{2-[1-(3-amino-propylcarbamoyl)ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester
CAS No.:1332760-71-0
Molecular Formula:C₂₁H₂₄FN₅O₄S
Molecular Weight:461.517
Hs Code.:

Synonyms:4-{2-[1-(3-amino-propylcarbamoyl)ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

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Chemical Property of 4-{2-[1-(3-amino-propylcarbamoyl)ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

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Technology Process of 4-{2-[1-(3-amino-propylcarbamoyl)ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

There total 8 articles about 4-{2-[1-(3-amino-propylcarbamoyl)ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332760-70-9
4-{2-[1-(3-tert-Butoxycarbonylamino-propylcarbamoyl)-ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

: 1332760-71-0
4-{2-[1-(3-amino-propylcarbamoyl)ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane;

Reference yield:

: 832113-96-9
methyl 4-chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylate

: 1332760-71-0
4-{2-[1-(3-amino-propylcarbamoyl)ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / 1,4-dioxane / 0.25 h / 140 °C / Microwave irradiation; Sealed tube

2.1: caesium carbonate / acetonitrile / 2 h / 60 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 0.25 h / 20 °C

4.2: 48 h / 50 °C

5.1: trifluoroacetic acid / dichloromethane

With caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

: 450-91-9
4-fluoro-2-methoxyaniline

: 1332760-71-0
4-{2-[1-(3-amino-propylcarbamoyl)ethoxy]-4-fluoro-phenylamino}-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane; water / 100 °C

2.1: boron tribromide / dichloromethane / 20 °C / Cooling with ice

2.2: 0.5 h / Cooling with ice; Reflux

3.1: caesium carbonate / acetonitrile / 2 h / 60 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile / 0.25 h / 20 °C

5.2: 48 h / 50 °C

6.1: trifluoroacetic acid / dichloromethane

With hydrogenchloride; boron tribromide; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; acetonitrile;