2-Bromo-3-iodo-benzoic acid

Base Information

• Chemical Name: 2-Bromo-3-iodo-benzoic acid
• CAS No.: 855198-37-7
• Molecular Formula: C₇H₄BrIO₂
• Molecular Weight: 326.916
• Hs Code.: 2916399090
• Mol file: 855198-37-7.mol

Synonyms:2-Bromo-3-iodo-benzoic acid

Chemical Property of 2-Bromo-3-iodo-benzoic acid

Chemical Property:

• Vapor Pressure: 2.45E-06mmHg at 25°C
• Melting Point: 159-162.5 °C
• Refractive Index: 1.693
• Boiling Point: 376.5°C at 760 mmHg
• PKA: 2.50±0.10(Predicted)
• Flash Point: 181.5°C
• PSA: 37.30000
• Density: 2.331g/cm³
• LogP: 2.75190
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

2-Bromo-3-iodobenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-3-iodo-benzoic acid

There total 1 articles about 2-Bromo-3-iodo-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-nitrophthalic acid (603-11-2) → 2-bromo-3-iodobenzoic acid (855198-37-7)

Guidance literature:

ueber mehrere Stufen;

DOI:10.1021/jo01149a009

Reference yield:

2-bromo-3-iodobenzoic acid (855198-37-7) → 2-(3-methoxyphenyl)-3-(2-{1H-pyrrolo[2,3-b]pyridin-3-yl}ethynyl)benzoic acid

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 12 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.2: 16 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 0.17 h / 130 °C / Sealed tube

4.2: 24 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; water; dimethyl sulfoxide;

Reference yield:

2-bromo-3-iodobenzoic acid (855198-37-7) → 2-bromo-3-ethynyl-benzoic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 12 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.2: 16 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In tetrahydrofuran; dimethyl sulfoxide;

upstream raw materials:

3-nitrophthalic acid