603-11-2Relevant articles and documents
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Littmann
, p. 1980 (1925)
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CO-production method 3 - nitro -2 - methyl benzoic acid and 3 -nitrophthalic acid (by machine translation)
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Paragraph 0019-0044, (2020/07/15)
The method comprises the following steps: (3 -) in nitric acid, oxidizing -2 - nitro-3 - methylbenzoic acid to 1 nitro 3 - methylbenzoic acid under the presence of a catalyst and an initiator; and (3 -) filtering to obtain the -2 -nitro 2 methylbenzoic acid crude product after the reaction is completed by heating while carrying out the reaction to complete the reaction and completing a 3 - nitro -2 -2 - methylbenzoic acid crude product after the reaction is completed, and the obtained crude 3 - product -2 - is obtained by recrystallizing the 4 mother liquor in the mother 3 - 1 liquor step (3) after the reaction is complete and the reaction is complete and the 3 - process is completed by carrying out the reaction on the 3 - mother liquor in the presence of a 3 - catalyst and an initiator to obtain the 3 -nitrobenzoic acid crude product. The method solves the problems of large waste water waste salt amount, difficult aftertreatment and serious environmental pollution in the prior art. (by machine translation)
Preparation of 2-phenyl-3-hydroxyquinoline-4(1H)-one-5-carboxamides as potential anticancer and fluorescence agents
Funk, Petr,Motyka, Kamil,D?ubák, Petr,Znojek, Pawel,Gurská, Soňa,Kusz, Joachim,McMaster, Claire,Hajdúch, Marián,Soural, Miroslav
, p. 48861 - 48867 (2015/06/16)
The synthesis of 3-hydroxyquinoline-4(1H)-one derivatives bearing substituted phenyl in position 2 and variously substituted carboxamide group in position 5 is described, with use of 3-nitrophthalic anhydride, α-haloketones and primary amines as the starting materials. The synthetic approach was inspired by the preparation of analogous derivatives reported previously. However, a different strategy had to be developed with the corresponding bis(phenacyl)-3-aminophthalates as the key intermediates. Synthesized hydroxyquinolinones, as well as their intermediates, were tested for their cytotoxic activity towards various cancer and non-malignant cell lines. The fluorescent properties of these compounds have also been evaluated. In both fields, interesting data were obtained and compared to isomeric compounds that have been studied in the past.