(4S,1R,5R,6R,8aR)-4-[(4-methoxyphenyl)methoxy]-5,8a-dimethyl-5-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphthalene-1,6-dicarbaldehyde

Base Information

• Chemical Name: (4S,1R,5R,6R,8aR)-4-[(4-methoxyphenyl)methoxy]-5,8a-dimethyl-5-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphthalene-1,6-dicarbaldehyde
• CAS No.: 1018479-87-2
• Molecular Formula: C₃₀H₄₈O₅Si
• Molecular Weight: 516.794
• Mol file: 1018479-87-2.mol

Synonyms:(4S,1R,5R,6R,8aR)-4-[(4-methoxyphenyl)methoxy]-5,8a-dimethyl-5-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphthalene-1,6-dicarbaldehyde

Chemical Property of (4S,1R,5R,6R,8aR)-4-[(4-methoxyphenyl)methoxy]-5,8a-dimethyl-5-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphthalene-1,6-dicarbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,1R,5R,6R,8aR)-4-[(4-methoxyphenyl)methoxy]-5,8a-dimethyl-5-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphthalene-1,6-dicarbaldehyde

There total 1 articles about (4S,1R,5R,6R,8aR)-4-[(4-methoxyphenyl)methoxy]-5,8a-dimethyl-5-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphthalene-1,6-dicarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{(1S,8S,4aS)-5-(hydroxymethyl)-8-[(4-methoxyphenyl)methoxy]-1,4a-dimethyl-1-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphth-2-yl}methan-1-ol (1018479-95-2) → (4S,1R,5R,6R,8aR)-4-[(4-methoxyphenyl)methoxy]-5,8a-dimethyl-5-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphthalene-1,6-dicarbaldehyde (1018479-87-2)

Guidance literature:

{(1S,8S,4aS)-5-(hydroxymethyl)-8-[(4-methoxyphenyl)methoxy]-1,4a-dimethyl-1-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphth-2-yl}methan-1-ol; With dipyridinium dichromate; sodium acetate; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere; Molecular sieve;

With sodium methylate; In methanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol800101v

Reference yield: 99.0%

2-ethyl-2-methyl-1,3-dioxolane (126-39-6) + (4S,1R,5R,6R,8aR)-4-[(4-methoxyphenyl)methoxy]-5,8a-dimethyl-5-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphthalene-1,6-dicarbaldehyde (1018479-87-2) → (8S,1R,2R,5R,4aR)-2,5-di(1,3-dioxolan-2-yl)-8-[(4-methoxyphenyl)methoxy]-1,4a-dimethyl-1-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphthalene (1018479-88-3)

Guidance literature:

With toluene-4-sulfonic acid; In ethylene glycol; at 40 ℃; for 7.5h; Inert atmosphere;

DOI:10.1021/ol800101v

upstream raw materials:

{(1S,8S,4aS)-5-(hydroxymethyl)-8-[(4-methoxyphenyl)methoxy]-1,4a-dimethyl-1-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphth-2-yl}methan-1-ol

Downstream raw materials:

(8S,1R,2R,5R,4aR)-2,5-di(1,3-dioxolan-2-yl)-8-[(4-methoxyphenyl)methoxy]-1,4a-dimethyl-1-[2-(tert-butyldimethylsilanyloxy)ethyl]perhydronaphthalene