5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-4-(3-nitrophenyl)-2H-chromen-2-one

Base Information

Chemical Name:5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-4-(3-nitrophenyl)-2H-chromen-2-one
CAS No.:1428553-78-9
Molecular Formula:C₂₈H₂₆N₂O₅
Molecular Weight:470.525
Hs Code.:

Synonyms:5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-4-(3-nitrophenyl)-2H-chromen-2-one

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Chemical Property of 5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-4-(3-nitrophenyl)-2H-chromen-2-one

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Technology Process of 5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-4-(3-nitrophenyl)-2H-chromen-2-one

There total 4 articles about 5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-4-(3-nitrophenyl)-2H-chromen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 110-91-8,99108-56-2
morpholine

: 1428554-15-7
6-bromo-5,7-dimethyl-4-(3-nitrophenyl)-2H-chromen-2-one

: 68162-47-0
4-bromomethylphenylboronic acid

: 1428553-78-9
5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-4-(3-nitrophenyl)-2H-chromen-2-one

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 130 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1428554-13-5
4-bromo-3,5-dimethylphenyl propiolate

: 1428553-78-9
5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-4-(3-nitrophenyl)-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 6.4 h / 65 °C / Inert atmosphere

2: trifluoroacetic acid; palladium diacetate / dichloromethane / 4.5 h / 0 - 20 °C

3: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.5 h / 130 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1428554-14-6
4-bromo-3,5-dimethylphenyl 3-(3-nitrophenyl)propiolate

: 1428553-78-9
5,7-dimethyl-6-(4-(morpholinomethyl)phenyl)-4-(3-nitrophenyl)-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; palladium diacetate / dichloromethane / 4.5 h / 0 - 20 °C

2: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.5 h / 130 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; potassium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;