68162-47-0

Usage

Uses

1. Used in Pharmaceutical Industry:
4-(Bromomethyl)phenylboronic acid is used as a reactant for the design of boronic acid-based autotaxin inhibitors. These inhibitors play a crucial role in the development of drugs targeting autotaxin, an enzyme involved in various diseases, including cancer and fibrosis.
2. Used in Chemical Synthesis:
In the field of chemical synthesis, 4-(Bromomethyl)phenylboronic acid is utilized as a key reactant in the synthesis of boronated phosphonium salts. These salts have potential applications in various chemical processes and materials science.
3. Used in Genetic Research:
4-(Bromomethyl)phenylboronic acid is used as a component in studies aimed at incorporating boronic acid groups to enhance gene transfection capability. This application is significant in the field of genetic research and gene therapy, as it can improve the efficiency of gene delivery and expression.
4. Used in Analytical Chemistry:
In analytical chemistry, 4-(Bromomethyl)phenylboronic acid is employed in investigations of the effect of boronic acid-positioning in optical glucose-sensing ensemble. This research is essential for the development of advanced glucose sensors and diagnostic tools for monitoring glucose levels in various applications, such as diabetes management.
5. Used in Suzuki Reaction:
4-(Bromomethyl)phenylboronic acid is also used as a reactant in the Suzuki reaction, a widely employed method for the formation of carbon-carbon bonds in organic synthesis. This reaction is crucial in the synthesis of various complex molecules and pharmaceutical compounds.

InChI:InChI=1/C7H8BBrO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4,10-11H,5H2

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 40881-45-6 4-tolylboronic dimethyl ester 
• 106-38-7 para-bromotoluene 

Downstream Products

• 101269-67-4 acetylamino-(4-dihydroxyboranyl-benzyl)-malonic acid diethyl ester 
• 436853-30-4 N,N'-4,4'-bis(benzyl-4''-boronic acid)bipyridinium dibromide 
• 143805-55-4 4-[(2-ethyl-5,6,7,8-tetrahydroquinolin-4-yl)oxymethyl]phenylboronic acid 
• 1036991-20-4 [4-(pyrrolidin-1-ylmethyl)phenyl]boronic acid 
• 1386439-51-5 1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethanone 
• 1421469-72-8 C₃₂H₂₈BN₂O₃⁽¹⁺⁾*Br^(1-) 

Relevant academic research and scientific papers

Indole and quinoline derivatives and its preparation method and application

The invention provides an indoloquinoline derivative, a preparation method and application thereof in preparing antitumor drugs and antiviral drugs. The chemical structure of the indoloquinoline derivative is shown as a formula I. Experiments show that a partly-boric-acid-modified indoloquinoline derivative and a non-boric-acid-modified indoloquinoline derivative have strong inhibition effect on various tumor cell strains, thereby being capable of being used for preparation of the antitumor drugs, and have strong antiviral activity, thereby being capable of being used for preparation of the antiviral drugs.

A light-driven rotaxane molecular shuttle with dual fluorescence addresses

A molecular shuttle containing an α-CD macrocycle, an azobenzene unit, and two different fluorescent naphthalimide units was synthesized. The cis-trans photoisomerization of the azobenzene unit resulted in the motion of the CD macrocycle on the track. Because of the easy regulation and full reversibility of the fluorescence change of the two stopper units, the molecular shuttle could be used as a molecular storage medium or switch with all-optical inputs and outputs.

Synthesis of (azidomethyl)phenylboronic acids

The synthesis of 2-, 3-, and 4-(azidomethyl)phenylboronic acids was carried out. The geometric and electronic structures were studied by quantum-chemical methods. The suggestion is made that there are weak intramolecular interactions between the boron atom and the nitrene nitrogen atom of the azido group.