(1S,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyl)-7-aza-bicyclo[4.1.0]hept-3-en-2-one

Base Information

Chemical Name:(1S,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyl)-7-aza-bicyclo[4.1.0]hept-3-en-2-one
CAS No.:627873-27-2
Molecular Formula:C₂₀H₂₉NO₃Si
Molecular Weight:359.541
Hs Code.:

Synonyms:(1S,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyl)-7-aza-bicyclo[4.1.0]hept-3-en-2-one

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Chemical Property of (1S,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyl)-7-aza-bicyclo[4.1.0]hept-3-en-2-one

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Technology Process of (1S,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyl)-7-aza-bicyclo[4.1.0]hept-3-en-2-one

There total 4 articles about (1S,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyl)-7-aza-bicyclo[4.1.0]hept-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 627873-25-0
(1S,5R,6R)-5-Hydroxy-7-(4-methoxy-benzyl)-7-aza-bicyclo[4.1.0]hept-3-en-2-one

: 627873-27-2
(1S,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyl)-7-aza-bicyclo[4.1.0]hept-3-en-2-one

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/ol035576i

Reference yield: 80.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 627873-18-1
(1aS,3aR,6aS,6bR)-1-(4-Methoxy-benzyl)-5,5-dimethyl-hexahydro-4,6-dioxa-1-aza-cyclopropa[e]inden-2-one

: 627873-27-2
(1S,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyl)-7-aza-bicyclo[4.1.0]hept-3-en-2-one

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jo402535j

Reference yield:

: 355401-57-9
(3aR,7aS)-6-iodo-2,2-dimethyl-3a,4,5,7a-tetrahydro-1,3-benzodioxol-5-one

: 627873-27-2
(1S,5R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyl)-7-aza-bicyclo[4.1.0]hept-3-en-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 0.416 g / 1,10-phenanthroline; Cs₂CO₃ / xylene / 0.5 h / 95 °C

2: 88 percent / NaOH / tetrahydrofuran / 0 °C

3: 80 percent / diisopropylethylamine; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 24 h / 20 °C

With dmap; sodium hydroxide; 1,10-Phenanthroline; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; xylene;
DOI:10.1021/ol035576i