dimethyl 2-(1-(4-chlorophenyl)-3-(4-(methoxymethoxy)phenyl)-3-oxopropyl)malonate

Base Information

Chemical Name:dimethyl 2-(1-(4-chlorophenyl)-3-(4-(methoxymethoxy)phenyl)-3-oxopropyl)malonate
CAS No.:1221964-48-2
Molecular Formula:C₂₂H₂₃ClO₇
Molecular Weight:434.873
Hs Code.:

Synonyms:dimethyl 2-(1-(4-chlorophenyl)-3-(4-(methoxymethoxy)phenyl)-3-oxopropyl)malonate

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Chemical Property of dimethyl 2-(1-(4-chlorophenyl)-3-(4-(methoxymethoxy)phenyl)-3-oxopropyl)malonate

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Technology Process of dimethyl 2-(1-(4-chlorophenyl)-3-(4-(methoxymethoxy)phenyl)-3-oxopropyl)malonate

There total 4 articles about dimethyl 2-(1-(4-chlorophenyl)-3-(4-(methoxymethoxy)phenyl)-3-oxopropyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1410102-52-1
(E)-3-(4-chlorophenyl)-1-(4-(methoxymethoxy)phenyl)prop-2-en-1-one

: 105-53-3
diethyl malonate

: 1221964-48-2
dimethyl 2-(1-(4-chlorophenyl)-3-(4-(methoxymethoxy)phenyl)-3-oxopropyl)malonate

Guidance literature:: With sodium hydride; In methanol; for 2h; Reflux;
DOI:10.1021/jm3010477

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1221964-48-2
dimethyl 2-(1-(4-chlorophenyl)-3-(4-(methoxymethoxy)phenyl)-3-oxopropyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 1 h / 20 °C

2: sodium hydride / methanol / 2 h / Reflux

With sodium hydride; sodium hydroxide; In methanol; ethanol; water; 1: |Claisen-Schmidt Condensation / 2: |Michael Addition;
DOI:10.1021/jm3010477