(R,R)-(-)-(trans)-2,3-bis(α-hydroxydiphenylmethyl)-1,4-dioxaspiro-[4.4]nonane

Base Information

Chemical Name:(R,R)-(-)-(trans)-2,3-bis(α-hydroxydiphenylmethyl)-1,4-dioxaspiro-[4.4]nonane
CAS No.:127103-49-5
Molecular Formula:C₃₃H₃₂O₄
Molecular Weight:492.615
Hs Code.:

Synonyms:(R,R)-(-)-(trans)-2,3-bis(α-hydroxydiphenylmethyl)-1,4-dioxaspiro-[4.4]nonane

Suppliers and Price of (R,R)-(-)-(trans)-2,3-bis(α-hydroxydiphenylmethyl)-1,4-dioxaspiro-[4.4]nonane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (R,R)-(-)-(trans)-2,3-bis(α-hydroxydiphenylmethyl)-1,4-dioxaspiro-[4.4]nonane

Chemical Property:

Purity/Quality:: >95%,>98%e.e. ^*data from raw suppliers

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Technology Process of (R,R)-(-)-(trans)-2,3-bis(α-hydroxydiphenylmethyl)-1,4-dioxaspiro-[4.4]nonane

There total 2 articles about (R,R)-(-)-(trans)-2,3-bis(α-hydroxydiphenylmethyl)-1,4-dioxaspiro-[4.4]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 100-58-3
phenylmagnesium bromide

: 198691-38-2
dimethyl 2,3-O-cyclopentylidene-L-tartrate

: 127103-49-5
(R,R)-(-)-(trans)-2,3-bis(α-hydroxydiphenylmethyl)-1,4-dioxaspiro-[4.4]nonane

Guidance literature:: In tetrahydrofuran; diethyl ether; 1.) reflux, 3 h, 2.) room temperature, 3 h;
DOI:10.1016/S0040-4020(97)00974-5

Reference yield:

: 120-92-3
cyclopentanone

: 127103-49-5
(R,R)-(-)-(trans)-2,3-bis(α-hydroxydiphenylmethyl)-1,4-dioxaspiro-[4.4]nonane

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / p-toluenesulfonic acid monohydrate / benzene / 164 h / Heating

2: 59 percent / tetrahydrofuran; diethyl ether / 1.) reflux, 3 h, 2.) room temperature, 3 h

With toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.1016/S0040-4020(97)00974-5