[(S)-9-(tert-Butyl-diphenyl-silanyloxy)-4-isopropenyl-14-(4-methoxy-benzyloxy)-11-methoxymethoxy-1,11-dimethyl-2-oxo-tetradeca-7,12-diynyl]-phosphonic acid dimethyl ester

Base Information

• Chemical Name: [(S)-9-(tert-Butyl-diphenyl-silanyloxy)-4-isopropenyl-14-(4-methoxy-benzyloxy)-11-methoxymethoxy-1,11-dimethyl-2-oxo-tetradeca-7,12-diynyl]-phosphonic acid dimethyl ester
• CAS No.: 191214-00-3
• Molecular Formula: C₄₇H₆₃O₉PSi
• Molecular Weight: 831.071
• Mol file: 191214-00-3.mol

Synonyms:[(S)-9-(tert-Butyl-diphenyl-silanyloxy)-4-isopropenyl-14-(4-methoxy-benzyloxy)-11-methoxymethoxy-1,11-dimethyl-2-oxo-tetradeca-7,12-diynyl]-phosphonic acid dimethyl ester

Chemical Property of [(S)-9-(tert-Butyl-diphenyl-silanyloxy)-4-isopropenyl-14-(4-methoxy-benzyloxy)-11-methoxymethoxy-1,11-dimethyl-2-oxo-tetradeca-7,12-diynyl]-phosphonic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-9-(tert-Butyl-diphenyl-silanyloxy)-4-isopropenyl-14-(4-methoxy-benzyloxy)-11-methoxymethoxy-1,11-dimethyl-2-oxo-tetradeca-7,12-diynyl]-phosphonic acid dimethyl ester

There total 11 articles about [(S)-9-(tert-Butyl-diphenyl-silanyloxy)-4-isopropenyl-14-(4-methoxy-benzyloxy)-11-methoxymethoxy-1,11-dimethyl-2-oxo-tetradeca-7,12-diynyl]-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-perillyl alcohol (536-59-4,18457-55-1) → [(S)-9-(tert-Butyl-diphenyl-silanyloxy)-4-isopropenyl-14-(4-methoxy-benzyloxy)-11-methoxymethoxy-1,11-dimethyl-2-oxo-tetradeca-7,12-diynyl]-phosphonic acid dimethyl ester (191214-00-3)

Guidance literature:

Multi-step reaction with 10 steps

1: 99 percent / VO(acac)2, t-BuOOH / CH₂Cl₂; decane / 0 - 20 °C

2: periodic acid / tetrahydrofuran; H₂O / 0 - 20 °C

3: p-TsOH

5: PPh₃

6: 1.) n-BuLi

7: imidazole / dimethylformamide

8: p-TsOH / H₂O

9: pyridinium dichromate

10: BuLi

With 1H-imidazole; tert.-butylhydroperoxide; dipyridinium dichromate; n-butyllithium; bis(acetylacetonate)oxovanadium; toluene-4-sulfonic acid; periodic acid; triphenylphosphine; In tetrahydrofuran; decane; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo970360d

Reference yield:

((4S)-4-(prop-1-en-2-yl)-7-oxabicyclo[4.1.0]heptan-1-yl)methanol (190718-78-6) → [(S)-9-(tert-Butyl-diphenyl-silanyloxy)-4-isopropenyl-14-(4-methoxy-benzyloxy)-11-methoxymethoxy-1,11-dimethyl-2-oxo-tetradeca-7,12-diynyl]-phosphonic acid dimethyl ester (191214-00-3)

Guidance literature:

Multi-step reaction with 9 steps

1: periodic acid / tetrahydrofuran; H₂O / 0 - 20 °C

2: p-TsOH

4: PPh₃

5: 1.) n-BuLi

6: imidazole / dimethylformamide

7: p-TsOH / H₂O

8: pyridinium dichromate

9: BuLi

With 1H-imidazole; dipyridinium dichromate; n-butyllithium; toluene-4-sulfonic acid; periodic acid; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1021/jo970360d

Reference yield:

(S)-7,7-dimethoxy-5-isopropenyl-1-heptyne (190718-43-5) → [(S)-9-(tert-Butyl-diphenyl-silanyloxy)-4-isopropenyl-14-(4-methoxy-benzyloxy)-11-methoxymethoxy-1,11-dimethyl-2-oxo-tetradeca-7,12-diynyl]-phosphonic acid dimethyl ester (191214-00-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) n-BuLi

2: imidazole / dimethylformamide

3: p-TsOH / H₂O

4: pyridinium dichromate

5: BuLi

With 1H-imidazole; dipyridinium dichromate; n-butyllithium; toluene-4-sulfonic acid; In water; N,N-dimethyl-formamide;

DOI:10.1021/jo970360d

upstream raw materials:

ethylphosphonic acid diethyl ester

(S)-8-(tert-Butyl-diphenyl-silanyloxy)-3-isopropenyl-13-(4-methoxy-benzyloxy)-10-methoxymethoxy-10-methyl-trideca-6,11-diynoic acid methyl ester

(-)-perillyl alcohol

((4S)-4-(prop-1-en-2-yl)-7-oxabicyclo[4.1.0]heptan-1-yl)methanol

Downstream raw materials:

[(S)-9-(tert-Butyl-diphenyl-silanyloxy)-4-isopropenyl-11-methoxymethoxy-1,11-dimethyl-2,14-dioxo-tetradeca-7,12-diynyl]-phosphonic acid dimethyl ester

(Z)-(S)-8-(tert-Butyl-diphenyl-silanyloxy)-13-isopropenyl-6-methoxymethoxy-2,6-dimethyl-cyclotetradec-2-ene-4,9-diynone

(Z)-(S)-8-(tert-Butyl-diphenyl-silanyloxy)-13-isopropenyl-6-methoxymethoxy-2,6-dimethyl-cyclotetradec-2-ene-4,9-diynol

[(S)-9-(tert-Butyl-diphenyl-silanyloxy)-14-hydroxy-4-isopropenyl-11-methoxymethoxy-1,11-dimethyl-2-oxo-tetradeca-7,12-diynyl]-phosphonic acid dimethyl ester