Technology Process of (O-<2-tosyloxy)ethyl>-D-serine)8-cyclosporin
There total 5 articles about (O-<2-tosyloxy)ethyl>-D-serine)8-cyclosporin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap;
In
dichloromethane;
for 6h;
Ambient temperature;
DOI:10.1021/jm00011a004
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 88 percent / tetraethylammonium chloride, 30percent NaOH / CH2Cl2 / 0.75 h / Ambient temperature
2: 81 percent / lithium borohydride / ethanol / 3 h / Ambient temperature
3: 95 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 6 h / Ambient temperature
With
dmap; sodium hydroxide; lithium borohydride; tetraethylammonium chloride;
In
ethanol; dichloromethane;
DOI:10.1021/jm00011a004
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 97 percent / CH3ONa / 3 h / Ambient temperature
2: lithium borohydride / ethanol / Ambient temperature
3: 95 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 6 h / Ambient temperature
With
dmap; lithium borohydride; sodium methylate;
In
ethanol; dichloromethane;
DOI:10.1021/jm00011a004
