Preparation and in Vitro Activities of Ethers of 8-cyclosporin

DOI: 10.1021/jm00011a004

Source and publish data:

Journal of Medicinal Chemistry p. 1853 - 1864 (1995)

Update date:2022-08-02

Topics:

Authors:

Eberle, Marcel K.

Hiestand, Peter

Jutzi-Eme, Anne-Marie

Nuninger, Francois

Zihlmann, Hans R.

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Article abstract of DOI:10.1021/jm00011a004

Reactions of the ⁸-cyclosporin (2) with a series of alkylating agents under phase transfer conditions gave the alkylated products 3-6.Alkylations of 2 with hindered esters of bromoacetate gave the crystalline esters 7 and 8.Hydrolysis

Full text of DOI:10.1021/jm00011a004

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Product name:O-acetyl-7,8-seco-<2(R)-piperidinecarboxylic acid>⁸-cyclosporin-7-thiocarboxylic acid S-benzyl ester

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