N-[3-(4-tert-butylphenyl)-1-pivaloyloxy-2-propyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea

Base Information

Chemical Name:N-[3-(4-tert-butylphenyl)-1-pivaloyloxy-2-propyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea
CAS No.:503597-33-9
Molecular Formula:C₂₉H₄₂N₂O₅S
Molecular Weight:530.729
Hs Code.:

Synonyms:N-[3-(4-tert-butylphenyl)-1-pivaloyloxy-2-propyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea

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Chemical Property of N-[3-(4-tert-butylphenyl)-1-pivaloyloxy-2-propyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea

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Technology Process of N-[3-(4-tert-butylphenyl)-1-pivaloyloxy-2-propyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea

There total 7 articles about N-[3-(4-tert-butylphenyl)-1-pivaloyloxy-2-propyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 2,2-dimethyl-propionic acid 2-amino-3-(4-tert-butyl-phenyl)-propyl ester; compound with trifluoro-acetic acid

: 289903-62-4
4-[(methoxylmethyl)oxy]-3-methoxybenzyl isothiocyanate

: 503597-33-9
N-[3-(4-tert-butylphenyl)-1-pivaloyloxy-2-propyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2003.12.005

Reference yield:

: 401573-47-5
ethyl 2-amino-3-(4-tert-butylphenyl)propanoate

: 503597-33-9
N-[3-(4-tert-butylphenyl)-1-pivaloyloxy-2-propyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / tetrahydrofuran / 16 h

2: 80 percent / LiAlH₄ / diethyl ether / 1 h / 20 °C

3: 99 percent / Et₃N; dimethylaminopyridine / CH₂Cl₂ / 1 h / 20 °C

4: CH₂Cl₂ / 3 h / 20 °C

5: 52 percent / Et₃N / CH₂Cl₂ / 20 °C

With dmap; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.bmc.2003.12.005

Reference yield:

: 401573-51-1
tert-butyl N-[2-(4-tert-butylphenyl)-1-(hydroxymethyl)ethyl]carbamate

: 503597-33-9
N-[3-(4-tert-butylphenyl)-1-pivaloyloxy-2-propyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / Et₃N; dimethylaminopyridine / CH₂Cl₂ / 1 h / 20 °C

2: CH₂Cl₂ / 3 h / 20 °C

3: 52 percent / Et₃N / CH₂Cl₂ / 20 °C

With dmap; triethylamine; In dichloromethane;
DOI:10.1016/j.bmc.2003.12.005