289903-62-4

Upstream product

• 463-71-8 thiophosgene 
• 210918-31-3 3-methoxy-4-methoxymethoxybenzylamine 
• 75-15-0 carbon disulfide 
• 1528740-63-7 C₁₀H₁₃N₃O₃ 
• 5533-01-7 [3-methoxy-4-(methoxymethoxy)phenyl]methanol 

Downstream Products

• 332105-06-3 2,2-dimethyl-propionic acid 2-benzyl-3-[3-(3-methoxy-4-methoxymethoxy-benzyl)-thioureido]-propyl ester 
• 1025985-78-7 2,2-dimethyl-propionic acid 2-(3,4-dimethyl-benzyl)-3-[3-(3-methoxy-4-methoxymethoxy-benzyl)-thioureido]-propyl ester 
• 503597-14-6 N-[4-(3,4-dimethylphenyl)-2-(pivaloyloxymethyl)butyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea 
• 503597-15-7 N-[4-(4-tert-butylphenyl)-2-(pivaloyloxymethyl)butyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea 
• 503597-32-8 N-[3-(3,4-dimethylphenyl)-1-pivaloyloxy-2-propyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea 
• 503597-34-0 N-[4-(3,4-dimethylphenyl)-1-pivaloyloxy-2-butyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea 
• 503597-33-9 N-[3-(4-tert-butylphenyl)-1-pivaloyloxy-2-propyl]-N'-[3-methoxy-4-(methoxymethoxy)benzyl]thiourea 

Relevant academic research and scientific papers

Asymmetric synthesis and receptor activity of chiral simplified resiniferatoxin (sRTX) analogues as transient receptor potential vanilloid 1 (TRPV1) ligands

The chiral isomers of the two potent simplified RTX-based vanilloids, compounds 2 and 3, were synthesized employing highly enantioselective PTC alkylation and evaluated as hTRPV1 ligands. The analysis indicated that the R-isomer was the eutomer in binding affinity and functional activity. The agonism of compound 2R was comparable to that of RTX. Docking analysis of the chiral isomers of 3 suggested the basis for its stereospecific activity and the binding mode of 3R.

Asymmetric synthesis and receptor activity of chiral simplified resiniferatoxin (sRTX) analogues as transient receptor potential vanilloid 1 (TRPV1) ligands

The chiral isomers of the two potent simplified RTX-based vanilloids, compounds 2 and 3, were synthesized employing highly enantioselective PTC alkylation and evaluated as hTRPV1 ligands. The analysis indicated that the R-isomer was the eutomer in binding affinity and functional activity. The agonism of compound 2R was comparable to that of RTX. Docking analysis of the chiral isomers of 3 suggested the basis for its stereospecific activity and the binding mode of 3R.

Asymmetric synthesis and receptor activity of chiral simplified resiniferatoxin (sRTX) analogues as transient receptor potential vanilloid 1 (TRPV1) ligands

The chiral isomers of the two potent simplified RTX-based vanilloids, compounds 2 and 3, were synthesized employing highly enantioselective PTC alkylation and evaluated as hTRPV1 ligands. The analysis indicated that the R-isomer was the eutomer in binding affinity and functional activity. The agonism of compound 2R was comparable to that of RTX. Docking analysis of the chiral isomers of 3 suggested the basis for its stereospecific activity and the binding mode of 3R.

AMINOTETRALIN-DERIVED UREA MODULATORS OF VANILLOID VR1 RECEPTOR

This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.