(R)-1-<1,1-(dimethylethoxycarbonyl)>-4-(2-hydroxy-1-phenylethyl)piperazin-3-one

Base Information

Chemical Name:(R)-1-<1,1-(dimethylethoxycarbonyl)>-4-(2-hydroxy-1-phenylethyl)piperazin-3-one
CAS No.:156022-75-2
Molecular Formula:C₁₇H₂₄N₂O₄
Molecular Weight:320.389
Hs Code.:

Synonyms:(R)-1-<1,1-(dimethylethoxycarbonyl)>-4-(2-hydroxy-1-phenylethyl)piperazin-3-one

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Chemical Property of (R)-1-<1,1-(dimethylethoxycarbonyl)>-4-(2-hydroxy-1-phenylethyl)piperazin-3-one

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Technology Process of (R)-1-<1,1-(dimethylethoxycarbonyl)>-4-(2-hydroxy-1-phenylethyl)piperazin-3-one

There total 7 articles about (R)-1-<1,1-(dimethylethoxycarbonyl)>-4-(2-hydroxy-1-phenylethyl)piperazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 180285-10-3
(R)-1-<1,1-(dimethylethoxycarbonyl)>-4-(4,4,5,5-tetramethyl-1-phenyl-3-oxa-4-sila-hexyl)piperazin-3-one

: 156022-75-2
(R)-1-<1,1-(dimethylethoxycarbonyl)>-4-(2-hydroxy-1-phenylethyl)piperazin-3-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1055/s-1996-4299

Reference yield:

: 4530-20-5
BOC-glycine

: 156022-75-2
(R)-1-<1,1-(dimethylethoxycarbonyl)>-4-(2-hydroxy-1-phenylethyl)piperazin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / DCC / CH₂Cl₂ / 7 h / 0 - 20 °C

2: 94 percent / LiAlH₄ / diethyl ether / 24 h / Ambient temperature

3: 80 percent / imidazole / dimethylformamide / 18 h / Ambient temperature

4: 1.) DCC / 1.) CH₂Cl₂, RT, 30 min, 2.) CH₂Cl₂, RT, 24 h

5: 73 percent / NaH / dimethylformamide; tetrahydrofuran / 3 h / Ambient temperature

6: 88 percent / nBu₄NF / tetrahydrofuran / 3 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-1996-4299

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 156022-75-2
(R)-1-<1,1-(dimethylethoxycarbonyl)>-4-(2-hydroxy-1-phenylethyl)piperazin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / DCC / CH₂Cl₂ / 7 h / 0 - 20 °C

2: 94 percent / LiAlH₄ / diethyl ether / 24 h / Ambient temperature

3: 80 percent / imidazole / dimethylformamide / 18 h / Ambient temperature

4: 1.) DCC / 1.) CH₂Cl₂, RT, 30 min, 2.) CH₂Cl₂, RT, 24 h

5: 73 percent / NaH / dimethylformamide; tetrahydrofuran / 3 h / Ambient temperature

6: 88 percent / nBu₄NF / tetrahydrofuran / 3 h / Ambient temperature

With 1H-imidazole; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-1996-4299