12-(4-chlorophenyl)-2-hydroxy-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one

Base Information

• Chemical Name: 12-(4-chlorophenyl)-2-hydroxy-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one
• CAS No.: 1352090-31-3
• Molecular Formula: C₂₅H₂₁ClO₃
• Molecular Weight: 404.893
• Mol file: 1352090-31-3.mol

Synonyms:12-(4-chlorophenyl)-2-hydroxy-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one

Chemical Property of 12-(4-chlorophenyl)-2-hydroxy-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 12-(4-chlorophenyl)-2-hydroxy-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one

There total 1 articles about 12-(4-chlorophenyl)-2-hydroxy-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2,7-Dihydroxynaphthalene (582-17-2) + 4-chlorobenzaldehyde (104-88-1) + dimedone (126-81-8) → 12-(4-chlorophenyl)-2-hydroxy-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one (1352090-31-3)

Guidance literature:

With toluene-4-sulfonic acid; 1-butyl-3-methylimidazolium Tetrafluoroborate; at 50 ℃; for 2h;

DOI:10.1002/jhet.661

Reference yield: 88.0%

12-(4-chlorophenyl)-2-hydroxy-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one (1352090-31-3) + propargyl bromide (106-96-7) + Phenyl azide (622-37-7) → 12-(4-chlorophenyl)-9,9-dimethyl-2-((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)-8,9,10,12-dihydro-8H-benzo[a]xanthen-11-one

Guidance literature:

With copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; at 80 ℃; for 0.833333h; Green chemistry;

DOI:10.5935/0103-5053.20140095

Reference yield: 84.0%

12-(4-chlorophenyl)-2-hydroxy-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one (1352090-31-3) + 4-azido-7-chloro-quinoline (69063-03-2) + propargyl bromide (106-96-7) → 2-((1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)methoxy)-12-(4-chlorophenyl)-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one

Guidance literature:

With copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; at 80 ℃; for 0.5h; Green chemistry;

DOI:10.5935/0103-5053.20140095

upstream raw materials:

2,7-Dihydroxynaphthalene

4-chlorobenzaldehyde

dimedone