(+)-(1R,2S,S_S)-N-[2-benzylamino-3-(t-butyldimethylsilyloxy)-1-(2-phenylethyl)prop-1-yl]-p-tolylsulfinamide

Base Information

• Chemical Name: (+)-(1R,2S,S_S)-N-[2-benzylamino-3-(t-butyldimethylsilyloxy)-1-(2-phenylethyl)prop-1-yl]-p-tolylsulfinamide
• CAS No.: 878556-87-7
• Molecular Formula: C₃₁H₄₄N₂O₂SSi
• Molecular Weight: 536.854

Synonyms:(+)-(1R,2S,S_S)-N-[2-benzylamino-3-(t-butyldimethylsilyloxy)-1-(2-phenylethyl)prop-1-yl]-p-tolylsulfinamide

Chemical Property of (+)-(1R,2S,S_S)-N-[2-benzylamino-3-(t-butyldimethylsilyloxy)-1-(2-phenylethyl)prop-1-yl]-p-tolylsulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(1R,2S,S_S)-N-[2-benzylamino-3-(t-butyldimethylsilyloxy)-1-(2-phenylethyl)prop-1-yl]-p-tolylsulfinamide

There total 1 articles about (+)-(1R,2S,S_S)-N-[2-benzylamino-3-(t-butyldimethylsilyloxy)-1-(2-phenylethyl)prop-1-yl]-p-tolylsulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

tert-butyldimethylsilyl chloride (18162-48-6) + (-)-(2S,3R,SS)-2-(benzylamino)-5-phenyl-3-(p-tolylsulfinylamino)pentan-1-ol (467471-30-3) → (+)-(1R,2S,SS)-N-[2-benzylamino-3-(t-butyldimethylsilyloxy)-1-(2-phenylethyl)prop-1-yl]-p-tolylsulfinamide (878556-87-7)

Guidance literature:

With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/jo052077h

Reference yield:

(+)-(1R,2S,SS)-N-[2-benzylamino-3-(t-butyldimethylsilyloxy)-1-(2-phenylethyl)prop-1-yl]-p-tolylsulfinamide (878556-87-7) → (+)-(5R,6S)-1-benzyl-6-(t-butyldimethylsilyloxymethyl)-5-(2-phenylethyl)-5,6-dihydro-1H-pyrazin-2-one (878556-98-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / aq. NaHCO₃ / ethyl acetate / 24 h / 0 - 20 °C

2: 86 percent / Cs₂CO₃ / dimethylformamide / 3.5 h / 65 °C

3: 87 percent / NaH / tetrahydrofuran / Heating

With sodium hydride; sodium hydrogencarbonate; caesium carbonate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jo052077h

Reference yield:

(+)-(1R,2S,SS)-N-[2-benzylamino-3-(t-butyldimethylsilyloxy)-1-(2-phenylethyl)prop-1-yl]-p-tolylsulfinamide (878556-87-7) → (2S,5S,6R)-4-Benzyl-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-oxo-6-phenethyl-piperazine-2-carbonitrile

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / aq. NaHCO₃ / ethyl acetate / 24 h / 0 - 20 °C

2: 86 percent / Cs₂CO₃ / dimethylformamide / 3.5 h / 65 °C

3: 87 percent / NaH / tetrahydrofuran / Heating

4: HOAc / tetrahydrofuran; H₂O / 20 °C

With sodium hydride; sodium hydrogencarbonate; caesium carbonate; acetic acid; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jo052077h

upstream raw materials:

tert-butyldimethylsilyl chloride

(-)-(2S,3R,S_S)-2-(benzylamino)-5-phenyl-3-(p-tolylsulfinylamino)pentan-1-ol

Downstream raw materials:

(+)-(5R,6S)-1-benzyl-6-(t-butyldimethylsilyloxymethyl)-5-(2-phenylethyl)-5,6-dihydro-1H-pyrazin-2-one

(+)-(5R,6S,S_S)-1-benzyl-6-[(t-butyldimethylsilyloxy)methyl]-5-(2-phenylethyl)-4-(p-tolylsulfinyl)piperazin-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 878556-87-7 (+)-(1R,2S,S_S)-N-[2-benzylamino-3-(t-butyldimethylsilyloxy)-1-(2-phenylethyl)prop-1-yl]-p-tolylsulfinamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send